| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 100mg | |||
| Other Sizes |
| Targets |
Beta-Cortol does not have a specific pharmacological target, as it is a metabolite of cortisol rather than a therapeutic agent. However, as a cortisol metabolite, it is involved in the metabolism and clearance of cortisol from the body. The compound is used as a biomarker for studying cortisol metabolism and adrenal function. Its levels in urine can provide information about cortisol production and metabolism.
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|---|---|
| ln Vitro |
In vitro studies on Beta-Cortol are not typically performed, as the compound is a metabolite used primarily as a reference standard and biomarker. The compound's role in cortisol metabolism has been characterized using analytical methods such as HPLC, GC-MS, and LC-MS/MS. These methods are used to quantify Beta-Cortol levels in biological samples for diagnostic and research purposes.
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| ln Vivo |
In vivo studies on Beta-Cortol are focused on its role as a biomarker for cortisol metabolism. The compound is measured in urine and other biological samples to assess cortisol production and metabolism in various clinical conditions, including adrenal insufficiency, Cushing's syndrome, and other glucocorticoid-related disorders. Elevated or reduced levels of Beta-Cortol can indicate alterations in cortisol metabolism and adrenal function.
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| Enzyme Assay |
The in vitro assays for Beta-Cortol are analytical rather than biological. The compound is used as a reference standard in HPLC, GC-MS, or LC-MS/MS methods for the quantification of cortisol metabolites in biological samples. In these assays, Beta-Cortol is analyzed alongside other cortisol metabolites to assess cortisol metabolism and adrenal function.
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| Cell Assay |
Cellular assays for Beta-Cortol are not performed, as the compound is a metabolite used for analytical and diagnostic purposes. The compound is not used in cell-based assays and is not studied for its effects on cells.
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| Animal Protocol |
In vivo animal studies for Beta-Cortol are not applicable. The compound is a metabolite used as a biomarker for studying cortisol metabolism and adrenal function in humans and animals. It is measured in biological samples but is not administered to animals for research purposes.
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| ADME/Pharmacokinetics |
Beta-Cortol has a molecular weight of approximately 364.48 and a molecular formula of C21H32O5. The compound is a solid at room temperature and is typically stored under appropriate conditions to maintain its stability. For research use, the compound is stored as powder at -20degC for up to 3 years or at 4degC for up to 2 years. The compound is soluble in organic solvents such as methanol, ethanol, and DMSO for analytical applications. Detailed pharmacokinetic parameters are not applicable.
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| Toxicity/Toxicokinetics |
Toxicological data for Beta-Cortol are not available, as the compound is a naturally occurring metabolite and is not a therapeutic agent. The compound is not intended for human or animal use. Standard safety precautions should be followed when handling the compound for research purposes.
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| References | |
| Additional Infomation |
β-cortisol is a corticosteroid hormone.
Beta-Cortol (CAS#: 667-65-2) is a metabolite of cortisol, the primary glucocorticoid hormone. It has a molecular formula of C21H32O5 and a molecular weight of approximately 364.48. The compound is used as a reference standard and research tool for studying cortisol metabolism, adrenal function, and glucocorticoid-related disorders. Beta-Cortol is not a therapeutic agent and is not approved for clinical use. |
| Molecular Formula |
C21H36O5
|
|---|---|
| Molecular Weight |
368.50754737854
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| Exact Mass |
368.256
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| CAS # |
667-65-2
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| PubChem CID |
246164
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| Appearance |
White to off-white solid powder
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| Density |
1.252g/cm3
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| Boiling Point |
564.5ºC at 760 mmHg
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| Flash Point |
255ºC
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| Index of Refraction |
1.586
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| LogP |
1.445
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| Hydrogen Bond Donor Count |
5
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
2
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| Heavy Atom Count |
26
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| Complexity |
555
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| Defined Atom Stereocenter Count |
10
|
| SMILES |
C[C@]12CC[C@H](C[C@H]1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4([C@@H](CO)O)O)C)O)O
|
| InChi Key |
FFPUNPBUZDTHJI-ZFOKFBPFSA-N
|
| InChi Code |
InChI=1S/C21H36O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-18,22-26H,3-11H2,1-2H3/t12-,13-,14+,15+,16+,17-,18-,19+,20+,21+/m1/s1
|
| Chemical Name |
(3R,5R,8S,9S,10S,11S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthrene-3,11,17-triol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~271.36 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.78 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (6.78 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (6.78 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7136 mL | 13.5682 mL | 27.1363 mL | |
| 5 mM | 0.5427 mL | 2.7136 mL | 5.4273 mL | |
| 10 mM | 0.2714 mL | 1.3568 mL | 2.7136 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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