| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
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| ln Vitro |
Benatezine hydrochloride and trofenin, which have Ki values of 0.010±0.001 and 0.003±0.000 mM, respectively, are commonly used anticholinergic medicines and competitive inhibitors of BChE. The findings indicate that benatizine hydrochloride has a purely competitive or partially competitive inhibitory impact on BChE. By graphing v versus [Benactyzine] at a fixed [BTCh][1], pure competitive inhibition may be separated from partial competitive inhibition.
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| ln Vivo |
The effects of benatrizine hydrochloride (1 mg/kg) on attentional responses were not noted. While acetylcholine-induced salivation is marginally reduced, the duration of the exploratory motor response is increased by benatrizine hydrochloride. Promazine and benatrizine hydrochloride almost completely reduce emotional reactions while having no effect on brain electrical epileptic seizure activity triggered by acetylcholine. Benazepam hydrochloride did not prevent emotional responses, but high dosages of promazine and imipramine did. Research suggests that benatirazine hydrochloride, promazine, and imipramine all have distinct effects on the autonomic effects of serotonin. The salivation phase brought on by a serotonin injection into the amygdala is inhibited and shortened by promazine, particularly benatizine hydrochloride [2].
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| References |
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| Additional Infomation |
A centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of cholinergic systems on behavior.
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| Molecular Formula |
C20H26CLNO3
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|---|---|
| Molecular Weight |
363.8783
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| Exact Mass |
363.16
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| CAS # |
57-37-4
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| PubChem CID |
66448
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| Appearance |
White to off-white solid powder
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| Density |
1.115g/cm3
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| Boiling Point |
409.3ºC at 760mmHg
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| Melting Point |
177-179 °C(lit.)
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| Flash Point |
201.4ºC
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| LogP |
3.609
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
9
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| Heavy Atom Count |
25
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| Complexity |
351
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
ZCEHOOLYWQBGQO-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C20H25NO3.ClH/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,23H,3-4,15-16H2,1-2H3;1H
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| Chemical Name |
2-(diethylamino)ethyl 2-hydroxy-2,2-diphenylacetate;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~150 mg/mL (~412.22 mM)
H2O : ~50 mg/mL (~137.41 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 25 mg/mL (68.70 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7482 mL | 13.7408 mL | 27.4816 mL | |
| 5 mM | 0.5496 mL | 2.7482 mL | 5.4963 mL | |
| 10 mM | 0.2748 mL | 1.3741 mL | 2.7482 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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