| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| Other Sizes |
| Targets |
Batilol does not have a specific protein target but acts as a biochemical precursor and modulator of lipid metabolism. It is used to synthesize amphiphilic alkylglycerolipids with antitumor activities and has been described as an inflammatory agent.
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|---|---|
| ln Vitro |
Cellular and biochemical studies use batilol as a precursor for the synthesis of bioactive alkylglycerolipids. It has been studied for its effects on inflammation and wound healing. The compound is also used in cosmetic formulations as a stabilizer and skin-conditioning agent.
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| ln Vivo |
Cellular studies use batilol to investigate the biological activities of alkylglycerols. Cells are treated with batilol or its derivatives, and endpoints include assessment of cell proliferation, apoptosis, and inflammatory responses. The compound has been studied for its potential in preventing or treating erythema, dermatitis, and promoting wound healing.
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| Enzyme Assay |
In vitro assays for batilol typically involve the synthesis of alkylglycerolipid derivatives and assessment of their biological activities. Cellular assays measure the effects of batilol and its derivatives on cell viability, proliferation, and inflammatory cytokine production. Lipid metabolism studies assess the incorporation of batilol into cellular membranes.
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| Cell Assay |
Cells are cultured and treated with batilol at concentrations ranging from 1-100 µM. Endpoints include assessment of cell viability by MTT, measurement of inflammatory markers by ELISA, and analysis of lipid composition by mass spectrometry. The compound's effects on wound healing are studied in scratch assays or similar models.
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| Animal Protocol |
In vivo studies have investigated batilol for the treatment of benzene poisoning and its effects on inflammation. The compound is typically administered orally or intraperitoneally. Endpoints include assessment of hematological parameters, inflammatory markers, and tissue histology.
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| ADME/Pharmacokinetics |
Batilol (C₂₁H₄₄O₃, MW 344.6) is a lipophilic compound. It has a melting point of 71-73°C and is used in cosmetic formulations. The compound is typically stored at room temperature. Detailed PK parameters have not been extensively characterized.
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| Toxicity/Toxicokinetics |
Batilol is generally considered safe for use in cosmetic products at appropriate concentrations. The compound has been described as an inflammatory agent in some contexts. No significant toxicity has been reported at concentrations used in research applications.
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| Additional Infomation |
Batilol is an alkylglycerol, formed when a primary hydroxyl group in glycerol is converted to the corresponding octadecyl ether. It is used in cosmetics as a stabilizer and skin conditioner. Batilol has been reported in Lobophytum, Sarcophyton crassocaule, and other organisms with relevant data. See also: Glycerides, C14-22 mono- (note moved to).
Batilol (batyl alcohol) is an alkylglycerol found naturally in shark liver oil and animal bone marrow. It is used as a precursor for the synthesis of antitumor alkylglycerolipids and as a cosmetic ingredient. The compound has been assigned the INN name batilol and the CAS number 544-62-7. It has been studied for potential therapeutic applications including wound healing and treatment of benzene poisoning. |
| Molecular Formula |
C21H44O3
|
|---|---|
| Molecular Weight |
344.58
|
| Exact Mass |
344.329
|
| CAS # |
544-62-7
|
| PubChem CID |
3681
|
| Appearance |
White to off-white solid powder
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| Density |
0.914g/cm3
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| Boiling Point |
471.1ºC at 760 mmHg
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| Melting Point |
71-73 °C(lit.)
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| Flash Point |
238.7ºC
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| Index of Refraction |
1.464
|
| LogP |
5.617
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
20
|
| Heavy Atom Count |
24
|
| Complexity |
221
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
OGBUMNBNEWYMNJ-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C21H44O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-24-20-21(23)19-22/h21-23H,2-20H2,1H3
|
| Chemical Name |
3-octadecoxypropane-1,2-diol
|
| Synonyms |
NSC284200 NSC-284200NSC 284200 Batilol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~8.33 mg/mL (~24.17 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (7.26 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (7.26 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.26 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9021 mL | 14.5104 mL | 29.0208 mL | |
| 5 mM | 0.5804 mL | 2.9021 mL | 5.8042 mL | |
| 10 mM | 0.2902 mL | 1.4510 mL | 2.9021 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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