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Purity: ≥98%
Bafetinib (formerly INNO406; NS-187), an investigational anticancer drug originally developed by Nippon Shinyaku and later licensed to CytRx, is an orally bioavailable dual Bcr-Abl/Lyn inhibitor with potential antineoplastic activity. It inhibits Bcr-Abl/Lyn with IC50s of 5.8 nM/19 nM in cell-free assays. In Bcr-Abl–positive KU812 mouse model, Bafetinib significantly inhibited tumor growth, and completely inhibited tumor growth without causing adverse effects at a dose of 20 mg/kg/day.
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| Additional Infomation |
Bafetinib is a biaryl compound. Bafetinib has been used in clinical trials to treat various cancers, including adult glioma, adult mixed glioma, adult glioblastoma, chronic myeloid leukemia, and acute lymphoblastic leukemia. Bafetinib is an orally effective 2-phenylaminopyrimidine derivative with potential antitumor activity. INNO-406 specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme resulting from the Philadelphia chromosome translocation associated with chronic myeloid leukemia (CML). Furthermore, the drug also inhibits the Src family member Lyn tyrosine kinase, which is upregulated in imatinib-resistant CML cells and various solid tumor cells. The inhibition of these specific tyrosine kinases by INNO-406 reduces cell proliferation and induces apoptosis. A significant proportion of CML patients are resistant to imatinib, sometimes due to point mutations in the Bcr/Abl fusion protein kinase domain. INNO-406 has dual inhibitory activity, has been shown to overcome this resistance, and is a potent drug for treating imatinib-resistant CML.
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| Molecular Formula |
C30H31F3N8O
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|---|---|
| Molecular Weight |
576.62
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| Exact Mass |
576.257
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| CAS # |
859212-16-1
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| Related CAS # |
859212-16-1;887650-05-7;
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| PubChem CID |
11387605
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| Appearance |
Light yellow to yellow solid powder
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| Density |
1.4±0.1 g/cm3
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| Melting Point |
166-168°C
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| Index of Refraction |
1.640
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| LogP |
3.03
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
11
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| Rotatable Bond Count |
8
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| Heavy Atom Count |
42
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| Complexity |
872
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| Defined Atom Stereocenter Count |
1
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| SMILES |
CC1=C(C=C(C=C1)NC(=O)C2=CC(=C(C=C2)CN3CC[C@@H](C3)N(C)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CN=C5
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| InChi Key |
ZGBAJMQHJDFTQJ-DEOSSOPVSA-N
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| InChi Code |
InChI=1S/C30H31F3N8O/c1-19-4-7-23(13-27(19)39-29-36-10-8-26(38-29)22-14-34-18-35-15-22)37-28(42)20-5-6-21(25(12-20)30(31,32)33)16-41-11-9-24(17-41)40(2)3/h4-8,10,12-15,18,24H,9,11,16-17H2,1-3H3,(H,37,42)(H,36,38,39)/t24-/m0/s1
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| Chemical Name |
(S)-N-(3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-3-(trifluoromethyl)benzamide
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| Synonyms |
INNO-406; INNO 406; NS187; NS187; INNO406;NS-187; NS 187
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (4.34 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (4.34 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. View More
Solubility in Formulation 3: 0.5% methylcellulose+0.2% Tween 80: 30 mg/mL |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7342 mL | 8.6712 mL | 17.3424 mL | |
| 5 mM | 0.3468 mL | 1.7342 mL | 3.4685 mL | |
| 10 mM | 0.1734 mL | 0.8671 mL | 1.7342 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT01215799 | Completed | Drug: Bafetinib | Hormone Refractory Prostate Cancer | CytRx | August 2010 | Phase 2 |
| NCT01144260 | Completed | Drug: bafetinib | B-Cell Chronic Lymphocytic Leukemia | CytRx | June 2010 | Phase 2 |
| NCT01234740 | Completed | Drug: bafetinib Procedure: microdialysis |
Adult Anaplastic Astrocytoma Adult Anaplastic Ependymoma |
City of Hope Medical Center | December 2010 | Phase 1 |
| NCT00352677 | Completed | Drug: INNO-406 | Chronic Myeloid Leukemia Acute Lymphocytic Leukemia |
CytRx | July 2006 | Phase 1 |
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