| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
AZ8838 is kept in a closed pocket [1]. In Ca2+ assay, AZ8838 is a strong antagonist of SLIGRL-NH2, having a pIC50 of 5.70 ± 0.02[1]. AZ8838 shown efficacy in suppressing IP1 synthesis (pIC50 = 5.84 ± 0.02) [1]. AZ8838 inhibits peptide-induced ERK1/2 phosphorylation (pIC50 = 5.7 ± 0.1) and β-arrestin-2 recruitment (pIC50 = 6.1 ± 0.1) [1].
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|---|---|
| ln Vivo |
A PAR2 agonist-induced rat paw edema model has demonstrated anti-inflammatory effects with AZ8838 (10 mg/kg; oral; 2 hours ago) [1].
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| Animal Protocol |
Animal/Disease Models: Wistar rat, acute edema model induced by PAR2 agonist 2f-LIGRLO-NH2 [1]
Doses: 10 mg/kg Route of Administration: Oral administration, once, 2 hrs (hrs (hours)) ago Experimental Results: demonstrated a 60% reduction in foot swelling . Inhibition of 2f-LIGRLO-NH2 induces activated mast cells, inhibition of 2f-LIGRLO-NH2 reduces tryptase-positive (AA1+ve) intact mast cells in the paw, and blocks histamine release. |
| References |
| Molecular Formula |
C13H15FN2O
|
|---|---|
| Molecular Weight |
234.269406557083
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| Exact Mass |
234.116
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| CAS # |
2100285-41-2
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| Related CAS # |
2100285-41-2 (S-isomer);2100283-63-2 (Racemate);2151021-59-7 (R-isomer);
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| PubChem CID |
126961334
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| Appearance |
Off-white to light yellow solid powder
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| LogP |
2.3
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
17
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| Complexity |
240
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| Defined Atom Stereocenter Count |
1
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| SMILES |
FC1C=CC([C@H](C2=NC=CN2)O)=C(C=1)CCC
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| InChi Key |
IDFPQEHZYBXIFO-LBPRGKRZSA-N
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| InChi Code |
InChI=1S/C13H15FN2O/c1-2-3-9-8-10(14)4-5-11(9)12(17)13-15-6-7-16-13/h4-8,12,17H,2-3H2,1H3,(H,15,16)/t12-/m0/s1
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| Chemical Name |
(S)-(4-fluoro-2-propylphenyl)-(1H-imidazol-2-yl)methanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~200 mg/mL (~853.72 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5 mg/mL (21.34 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 5 mg/mL (21.34 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 5 mg/mL (21.34 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.2686 mL | 21.3429 mL | 42.6858 mL | |
| 5 mM | 0.8537 mL | 4.2686 mL | 8.5372 mL | |
| 10 mM | 0.4269 mL | 2.1343 mL | 4.2686 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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