| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| 250mg | |||
| Other Sizes |
| Animal Protocol |
For the mammary carcinogenesis study, female Sprague-Dawley rats were administered Auraptene at 500 ppm in the diet. The effect on tumor latency and incidence was assessed in the N-methylnitrosourea (MNU)-induced model. [2]
To measure tissue drug levels, rats were fed a diet containing Auraptene at either 200 or 500 ppm. Mammary tissue was collected and analyzed by HPLC to detect the concentration of Auraptene. [2] |
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| References |
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| Additional Infomation |
Auraptene belongs to the coumarin class of compounds, and its structure is similar to that of umbelliferone, except that the hydrogen on the phenolic hydroxyl group is replaced by a geranyl group. Auraptene has been isolated from various edible fruits and vegetables and possesses a variety of therapeutic effects. It can function as a plant metabolite, antitumor agent, apoptosis inducer, dopaminergic agonist, neuroprotective agent, antihypertensive agent, γ-secretase regulator, wound healing agent, EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor, PPARα agonist, gastrointestinal drug, matrix metalloproteinase inhibitor, antioxidant, and hepatoprotective agent. It belongs to the coumarin class of compounds and is also a monoterpene compound. Functionally, it is related to umbelliferone. Auraptene has been reported in Sinacalia tangutica, Polygala paniculata, and other organisms with available data.
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| Molecular Formula |
C19H22O3
|
|---|---|
| Molecular Weight |
298.38
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| Exact Mass |
298.156
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| CAS # |
495-02-3
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| PubChem CID |
1550607
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| Appearance |
Off-white to light yellow solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
455.5±45.0 °C at 760 mmHg
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| Melting Point |
66 °C
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| Flash Point |
195.4±23.3 °C
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| Vapour Pressure |
0.0±1.1 mmHg at 25°C
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| Index of Refraction |
1.549
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| LogP |
5.69
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
22
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| Complexity |
469
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O(C1C([H])=C([H])C2C([H])=C([H])C(=O)OC=2C=1[H])C([H])([H])/C(/[H])=C(\C([H])([H])[H])/C([H])([H])C([H])([H])/C(/[H])=C(\C([H])([H])[H])/C([H])([H])[H]
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| InChi Key |
RSDDHGSKLOSQFK-RVDMUPIBSA-N
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| InChi Code |
InChI=1S/C19H22O3/c1-14(2)5-4-6-15(3)11-12-21-17-9-7-16-8-10-19(20)22-18(16)13-17/h5,7-11,13H,4,6,12H2,1-3H3/b15-11+
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| Chemical Name |
7-[(2E)-3,7-dimethylocta-2,6-dienoxy]chromen-2-one
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| Synonyms |
7-GeranyloxycoumarinAuraptenAuraptene
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~167.57 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (6.97 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (6.97 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (6.97 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3514 mL | 16.7572 mL | 33.5143 mL | |
| 5 mM | 0.6703 mL | 3.3514 mL | 6.7029 mL | |
| 10 mM | 0.3351 mL | 1.6757 mL | 3.3514 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT04744922 | COMPLETED | Dietary Supplement: Extracts of citrus peels standardized in AUR and NAR (phytocomplex). |
Subjective Cognitive Decline | IRCCS Centro San Giovanni di Dio Fatebenefratelli | 2021-04-07 | Not Applicable |
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