| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
In HEK293A cells, the IC50 value of auglurant (VU0424238) is 14 nM. Additionally, it binds to a K i value of 4.4 nM in HEK293A cells, which is a recognized allosteric site.
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| ln Vivo |
At an oral dose of 0.8 mg/kg, auglurant (VU0424238) displays 50% mGlu5 PET ligand occupancy in rats and has a clearance of 19.3 mL/min/kg. Additionally, at an oral dosage of 0.06 mg/kg, it exhibits 50% mGlu5 PET ligand occupancy in baboons and a clearance of 15.5 mL/min/kg in cynomolgus monkeys [1].
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| References |
| Molecular Formula |
C16H12FN5O2
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|---|---|
| Molecular Weight |
325.297185897827
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| Exact Mass |
325.098
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| CAS # |
1396337-04-4
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| PubChem CID |
60168069
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| Appearance |
Light yellow to yellow solid powder
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| LogP |
2.831
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
24
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| Complexity |
421
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
RBAHIIPVJVMACF-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H12FN5O2/c1-10-4-12(24-13-7-18-9-19-8-13)5-14(21-10)16(23)22-15-3-2-11(17)6-20-15/h2-9H,1H3,(H,20,22,23)
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| Chemical Name |
N-(5-fluoropyridin-2-yl)-6-methyl-4-pyrimidin-5-yloxypyridine-2-carboxamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~22.73 mg/mL (~69.87 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (6.39 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0741 mL | 15.3704 mL | 30.7409 mL | |
| 5 mM | 0.6148 mL | 3.0741 mL | 6.1482 mL | |
| 10 mM | 0.3074 mL | 1.5370 mL | 3.0741 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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