| Size | Price | Stock | Qty |
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| 10mg |
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| 50mg |
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| Other Sizes |
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| ln Vitro |
IgE-induced TNF-α and IL-6 production and expression in RBL-2H3 cells are dose-dependently inhibited by aucubin (0.001-1 μg/mL; actual 30 minutes) with IC50 values of 0.101 and 0.19 μg/mL[2]. Aucubin (0.01 μg/mL; rest for 30 minutes) inhibits IgE-induced nuclear translocation of NF-κB p65 subunit and degrades IκBα in RBL-2H3 cells [2]. Aucubin rises (0.001–1 mM; 12 h). PC12 cell survival and strongly reduced H2O2-induced fluorescence in cells [4].
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|---|---|
| ln Vivo |
In streptozotocin-induced diabetes, aucubin (5 mg/kg/d; intraperitoneal injection; 15 d) has protective effects on the pancreas and antioxidant properties [1]. In BLM-stimulated mice, aucubin (40–200 mg/kg; intraperitoneal injection, single dose) and aucubin (5 mg/kg/d; intraperitoneal injection; 21 days) decrease respiratory frequency, increase lung dynamic compliance, comprehend alterations in pulmonary parenchymal fibrosis, and lessen collagen deposition and inflammatory damage in the lungs [6].
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| Animal Protocol |
Animal/Disease Models: Diabetes induced by injection of streptozotocin in male Wistar rats (200-230 g) [1]
Doses: 5 mg/kg Route of Administration: intraperitoneal (ip) injection, twice (two times) daily for the first 5 days, then at the end Results of daily injections for 10 days: Weight gain in streptozotocin-treated diabetic rats. Lowers blood sugar levels. Reduces lipid peroxidation levels and increases antioxidant enzyme activity. Insulin immunoreactivity and the number of immunoreactive beta cells were increased compared with untreated diabetic rats. |
| References | |
| Additional Infomation |
Aucubin is an organic molecular entity. It has a role as a metabolite.
Aucubin has been reported in Veronica kellereri, Plantago uniflora, and other organisms with data available. See also: Chaste tree fruit (part of); Rehmannia glutinosa Root (part of); Plantago ovata seed (part of). |
| Molecular Formula |
C15H22O9
|
|---|---|
| Molecular Weight |
346.3298
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| Exact Mass |
346.126
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| CAS # |
479-98-1
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| PubChem CID |
91458
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| Appearance |
White to light yellow solid powder
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| Density |
1.6±0.1 g/cm3
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| Boiling Point |
669.0±55.0 °C at 760 mmHg
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| Melting Point |
180 - 184ºC
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| Flash Point |
358.4±31.5 °C
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| Vapour Pressure |
0.0±4.6 mmHg at 25°C
|
| Index of Refraction |
1.660
|
| LogP |
-3.17
|
| Hydrogen Bond Donor Count |
6
|
| Hydrogen Bond Acceptor Count |
9
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
24
|
| Complexity |
507
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| Defined Atom Stereocenter Count |
9
|
| SMILES |
C1=CO[C@H]([C@H]2[C@@H]1[C@@H](C=C2CO)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O
|
| InChi Key |
RJWJHRPNHPHBRN-FKVJWERZSA-N
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| InChi Code |
InChI=1S/C15H22O9/c16-4-6-3-8(18)7-1-2-22-14(10(6)7)24-15-13(21)12(20)11(19)9(5-17)23-15/h1-3,7-21H,4-5H2/t7-,8+,9+,10+,11+,12-,13+,14-,15-/m0/s1
|
| Chemical Name |
(2S,3R,4S,5S,6R)-2-[[(1S,4aR,5S,7aS)-5-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~288.74 mM)
H2O : ≥ 100 mg/mL (~288.74 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.22 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.22 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. View More
Solubility in Formulation 3: 2.5 mg/mL (7.22 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8874 mL | 14.4371 mL | 28.8742 mL | |
| 5 mM | 0.5775 mL | 2.8874 mL | 5.7748 mL | |
| 10 mM | 0.2887 mL | 1.4437 mL | 2.8874 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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