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    AT-7519 diHCl
    AT-7519 diHCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V11793
    CAS #: 902135-91-5Purity ≥98%

    Description: AT-7519 diHCl is a novel and potent multi-CDK (cyclin-dependent kinase) inhibitor for Cdk1/cyclin B, Cdk2/Cyclin A, Cdk3/Cyclin E, Cdk4/Cyclin D1, Cdk5/p35, and Cdk6/Cyclin D3 with IC50s of 210, 47, 100, 13, 170, and<10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively. AT7519 is an ATP competitive Cdk inhibitor but is inactive against all non-Cdk kinases with the exception of GSK3β. AT7519 shows potent antiproliferative activity in a variety of human tumor cell lines such as SW620. AT7519 induces activation of GSK-3β by down-regulating GSK-3β phosphorylation, which also contributes to AT7519 induced apoptosis independent of the inhibition of transcription. 

    References:

    [4]. Komiyama T, Kihara H, Hirose K, Yoshimoto R, Shigematsu H. AT-1015, a novel serotonin2A receptor antagonist, improves resaturation of exercised ischemic muscle in hypercholesterolemic rabbits. J Vasc Surg. 2004 Mar;39(3):661-7.  

    Related CAS #: 902135-91-5 (HCl)   844442-38-2 (free base)  

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    Related CAS #: 902135-91-5 (HCl)   844442-38-2 (free base)    

    Synonym: AT7519; AT-7519; AT 7519; AT-7519 diHCl.

    Chemical Name: N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide dihydrochloride



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