| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 100mg | |||
| Other Sizes |
| ln Vitro |
Asperphenamate completely induces autophagy, which suppresses the growth of cancer cells. In addition to having a modest inhibitory impact on cathepsin S, asperphenamate also inhibits cathepsin L.
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| References | |
| Additional Infomation |
Asperphenamate ester is a carboxylic acid ester formed by the condensation of the carboxyl group of N-benzoyl-L-phenylalanine and the hydroxyl group of N-benzoyl-L-phenylalanine. It is a metabolite found in various Penicillium and Aspergillus fungi, as well as plants, and is a product of endophytic fungi. It possesses antitumor activity. Asperphenamate ester is a derivative of L-phenylalanine, belonging to the benzamide class of compounds, and is also a carboxylic acid ester. Functionally, it is related to both N-benzoyl-L-phenylalanine and N-benzoyl-L-phenylalanine. Asperphenamate ester has been reported to exist in Begonia nantoensis, Artemisia anomala, and other organisms with relevant data.
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| Molecular Formula |
C32H30N2O4
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|---|---|
| Molecular Weight |
506.5916
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| Exact Mass |
506.221
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| CAS # |
63631-36-7
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| PubChem CID |
173952
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| Appearance |
White to off-white solid powder
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| Density |
1.198g/cm3
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| Boiling Point |
774.3ºC at 760 mmHg
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| Flash Point |
422.1ºC
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| Index of Refraction |
1.611
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| LogP |
5.394
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
12
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| Heavy Atom Count |
38
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| Complexity |
732
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| Defined Atom Stereocenter Count |
2
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| SMILES |
C1=CC=C(C=C1)C[C@@H](COC(=O)[C@H](CC2=CC=CC=C2)NC(=O)C3=CC=CC=C3)NC(=O)C4=CC=CC=C4
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| InChi Key |
CVULDJMCSSACEO-VMPREFPWSA-N
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| InChi Code |
InChI=1S/C32H30N2O4/c35-30(26-17-9-3-10-18-26)33-28(21-24-13-5-1-6-14-24)23-38-32(37)29(22-25-15-7-2-8-16-25)34-31(36)27-19-11-4-12-20-27/h1-20,28-29H,21-23H2,(H,33,35)(H,34,36)/t28-,29-/m0/s1
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| Chemical Name |
[(2S)-2-benzamido-3-phenylpropyl] (2S)-2-benzamido-3-phenylpropanoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~197.40 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (4.93 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9740 mL | 9.8699 mL | 19.7398 mL | |
| 5 mM | 0.3948 mL | 1.9740 mL | 3.9480 mL | |
| 10 mM | 0.1974 mL | 0.9870 mL | 1.9740 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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