| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| Other Sizes |
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| ln Vitro |
In a concentration- and time-dependent manner, arctigenin (0.01-1 μg/mL; 0.5-24 h) demonstrates preferential cytotoxicity to the PANC-1 cell line under nutrient-starved conditions [1]. In situations of nutrient deficiency, arctigenin (0.01-1 μg/mL; 0.5-24 h) inhibits the survival of several cancer cell lines (ASPC-1, BXPC-3, Alexander, and PSN-1 cells) [1]. In PANC-1 cells, arctigenin (0.1–1 μg/mL; 24 hours) totally prevents glucose deprivation-stimulated Akt phosphorylation [1]. With an IC50 of 2.9 μM, arctigenin (5–25 μM) exhibits strong in vitro antiviral activity against the influenza A virus[3].
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|---|---|
| ln Vivo |
Arctigenin (250 μg/mL; 0.2 mL; intraperitoneally administered 6 times per week for 9 weeks) suppresses the formation of PANC-1 tumors in nude mice [1]. ?Arctigenin (10 mg/kg; daily intraperitoneal injection for 30 days) alleviates the symptoms of experimental autoimmune encephalomyelitis (EAE) in mice [4].
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| Animal Protocol |
Animal/Disease Models: Female SPF/VAF BALB/cAn Ncrj-nu/nu (nude) mice were injected with PANC-1 cells [1]
Doses: 250 μg/mL, 0.2 mL Route of Administration: intraperitoneal (ip) injection 6 times a week for 9 weeks Experimental Results: Tumors shrink in weight and size. No significant weight loss was noted. |
| References |
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| Additional Infomation |
(-)-Arctigenin is a lignan.
Arctigenin has been reported in Saussurea parviflora, Saussurea salicifolia, and other organisms with data available. See also: Lignan (subclass of); Arctium lappa fruit (part of); Arctium lappa Root (part of) ... View More ... |
| Molecular Formula |
C21H24O6
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|---|---|
| Molecular Weight |
372.4117
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| Exact Mass |
372.157
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| CAS # |
7770-78-7
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| Related CAS # |
25488-59-9 (methyl ether); 26788-57-8 (mustard);
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| PubChem CID |
64981
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
567.0±45.0 °C at 760 mmHg
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| Melting Point |
100 °C
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| Flash Point |
198.8±22.2 °C
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| Vapour Pressure |
0.0±1.6 mmHg at 25°C
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| Index of Refraction |
1.576
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| LogP |
2.47
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
27
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| Complexity |
483
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| Defined Atom Stereocenter Count |
2
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| SMILES |
COC1=C(C=C(C=C1)C[C@H]2COC(=O)[C@@H]2CC3=CC(=C(C=C3)O)OC)OC
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| InChi Key |
NQWVSMVXKMHKTF-JKSUJKDBSA-N
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| InChi Code |
InChI=1S/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1
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| Chemical Name |
(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~268.52 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.71 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (6.71 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (6.71 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6852 mL | 13.4261 mL | 26.8521 mL | |
| 5 mM | 0.5370 mL | 2.6852 mL | 5.3704 mL | |
| 10 mM | 0.2685 mL | 1.3426 mL | 2.6852 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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