| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
|
||
| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Absorption is rapid, and excretion is rapid. |
|---|---|
| Additional Infomation |
Pentyl-m-cresol is a phenolic compound with a structure similar to m-cresol, but with an pentyl group substituted at the 6-position. It is an antibacterial agent with similar functions to m-cresol. Pentyl-m-cresol is an over-the-counter antibacterial agent available in Canada in various lozenges for the treatment of sore throat and minor oral infections. Pentyl-m-cresol is often formulated with dichlorobenzyl alcohol and menthol in common sore throat lozenges, such as Strepsils. Acute sore throat (pharyngitis) is one of the most common conditions seen in children at primary care facilities. Pharyngitis is usually caused by a virus, is generally benign, and self-limiting. Clinically proven over-the-counter throat lozenges provide rapid and effective relief of acute sore throat symptoms and are playing an increasingly important role in the treatment of this condition. Indications: Sore throat, mild oral and throat infections… Mechanism of Action: Its antiviral mechanism is not fully understood, but studies suggest it may work by denaturing viral external protein spikes, pH-induced rearrangement of attachment proteins' tertiary structure, or selectively acting on the viral lipid membrane/protein-lipid interactions. Pentocresol is an antibacterial and antiviral drug that blocks voltage-gated sodium channels in a manner similar to local anesthetics. Pharmacodynamics: Pentocresol throat lozenges significantly reduce the infectivity of certain infectious viruses in the throat and cough droplets, thereby reducing the chance of human-to-human transmission. It also relieves sore throat/throat irritation symptoms. Pentocresol is believed to inhibit inflammatory and pain mediators involved in oral and throat mucosal inflammation and sore throat.
|
| Molecular Formula |
C12H18O
|
|---|---|
| Molecular Weight |
178.27072
|
| Exact Mass |
178.136
|
| CAS # |
1300-94-3
|
| PubChem CID |
14759
|
| Appearance |
Light yellow to yellow liquid（Density：0.9414 g/cm3）
|
| Density |
0.955g/cm3
|
| Boiling Point |
273.2ºC at 760 mmHg
|
| Melting Point |
24°C
|
| Flash Point |
125.3ºC
|
| Vapour Pressure |
0.00348mmHg at 25°C
|
| Index of Refraction |
1.516
|
| LogP |
3.433
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
13
|
| Complexity |
133
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CCCCCC1=C(C=C(C)C=C1)O
|
| InChi Key |
CKGWFZQGEQJZIL-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C12H18O/c1-3-4-5-6-11-8-7-10(2)9-12(11)13/h7-9,13H,3-6H2,1-2H3
|
| Chemical Name |
5-methyl-2-pentylphenol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~560.95 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (14.02 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (14.02 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (14.02 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.6095 mL | 28.0473 mL | 56.0947 mL | |
| 5 mM | 1.1219 mL | 5.6095 mL | 11.2189 mL | |
| 10 mM | 0.5609 mL | 2.8047 mL | 5.6095 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT03944655 | COMPLETED | Drug: Strepsils Anaesthetic Formula Dietary Supplement: Clear Mint Drops |
Post Operative Sore Throat Sore Throat |
Dr Sebastian Sundaraj | 2019-01-17 | Not Applicable |
Products are for research use only; We do not sell to patients
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