| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
Amoxalin hydrochloride attaches to the carotene linkage and stops replication when it is exposed to light. Amoxalin hydrochloride that has been activated by light attaches to DNA and creates a permanent cross-link, which inhibits replication and halts the growth of donor T cells [1].
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| References | |
| Additional Infomation |
Amotosalen Hydrochloride is the hydrochloride salt form of amotosalen, a synthetic psoralen and light-activated DNA, RNA crosslinking agent, with protective activity against pathogens such as bacteria, viruses, protozoa, and leukocytes. Prior to administration amotosalen is added to plasma and platelets, then in vivo the agent penetrates pathogens and targets DNA and RNA. Upon activation by ultraviolet A light, this agent is able to form interstrand DNA and RNA crosslinks and prevents replication. Inactivation of leukocytes can prevent graft versus host disease upon transfusion.
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| Molecular Formula |
C17H19NO4.HCL
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|---|---|
| Molecular Weight |
337.798
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| Exact Mass |
337.108
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| CAS # |
161262-45-9
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| Related CAS # |
161262-45-9 (HCl);161262-29-9;
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| PubChem CID |
159598
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| Appearance |
White to light yellow solid powder
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| Boiling Point |
488.8ºC at 760mmHg
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| Flash Point |
249.4ºC
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| Vapour Pressure |
1.06E-09mmHg at 25°C
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| LogP |
4.442
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
23
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| Complexity |
464
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| Defined Atom Stereocenter Count |
0
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| SMILES |
Cl.NCCOCC1=C(C)OC2C(=C3OC(=O)C=C(C)C3=CC1=2)C
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| InChi Key |
MHLAMQBABOJZQW-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C17H19NO4.ClH/c1-9-6-15(19)22-16-10(2)17-13(7-12(9)16)14(11(3)21-17)8-20-5-4-18;/h6-7H,4-5,8,18H2,1-3H3;1H
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| Chemical Name |
3-(2-aminoethoxymethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~7.14 mg/mL (~21.14 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.71 mg/mL (2.10 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 7.1 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.71 mg/mL (2.10 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 7.1 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 0.71 mg/mL (2.10 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9603 mL | 14.8017 mL | 29.6033 mL | |
| 5 mM | 0.5921 mL | 2.9603 mL | 5.9207 mL | |
| 10 mM | 0.2960 mL | 1.4802 mL | 2.9603 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT05128084 | Unknown status | Congenital Heart Disease in Children | University Hospital, Strasbourg, France | 2020-10-01 | ||
| NCT05162378 | Unknown status | Heart Surgery | University Hospital, Strasbourg, France | 2020-10-21 | ||
| NCT04372979 | Terminated | Drug: Transfusion of SARS-CoV-2 Convalescent Plasma. Drug: Transfusion of standard Plasma. |
COVID-19 | Direction Centrale du Service de Santé des Armées | 2020-09-14 | Phase 3 |
| NCT04389944 | Completed | Other: convalescent plasma application to SARS-CoV-2 infected patients |
Coronavirus Disease 2019 Infectious Disease (COVID-19 Infection) |
University Hospital, Basel, Switzerland | 2020-03-31 | Not Applicable |
| NCT06291025 | Not yet recruiting | Procedure: PEX-FREE | Thrombotic Microangiopathies | University Hospital, Rouen | 2024-04-01 | Not Applicable |
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