| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| Other Sizes |
| Additional Infomation |
α-Tocotrienol is a tocotrienol with the structure chroman-6-ol, substituted with methyl groups at positions 2, 5, 7, and 8, and a farnesyl chain at position 2. It is found in the palm oil of oil palm (Elaeis guineensis). α-Tocotrienol has neuroprotective effects and is a plant metabolite, an inhibitor of ferroptosis, and a human metabolite. It is a tocotrienol and also a form of vitamin E. Tocotrienols have been investigated for their use in cholesterol-lowering treatments. α-Tocotrienol has been reported in amaranth (Amaranthus cruentus), humans (Homo sapiens), and other organisms with relevant data. Tocotrienols are any of the four forms (α, β, γ, and δ) of the vitamin E family and possess potential cholesterol-lowering, antithrombotic, antioxidant, immunomodulatory, and antitumor activities. Tocotrienols inhibit the activity of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, thereby lowering cholesterol levels. Furthermore, tocotrienols induce cell cycle arrest and caspase-mediated apoptosis through multiple signal transduction pathways and reduce tumor cell proliferation. This compound may also inhibit angiogenesis by blocking the vascular endothelial growth factor receptor (VEGFR) and subsequently inhibiting tumor cell-induced angiogenesis. Simultaneously, this compound can prevent free radical generation and inhibit lipid peroxidation, thereby preventing DNA damage. The farnesylisoprene side chain of tocotrienols contains three double bonds (a structure absent in tocopherols), which may be one reason for its anticancer activity.
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| Molecular Formula |
C29H44O2
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|---|---|
| Molecular Weight |
424.65846
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| Exact Mass |
424.334
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| CAS # |
58864-81-6
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| PubChem CID |
5282347
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| Appearance |
Colorless to light yellow ointment
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
541.7±50.0 °C at 760 mmHg
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| Flash Point |
222.3±24.4 °C
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| Vapour Pressure |
0.0±1.5 mmHg at 25°C
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| Index of Refraction |
1.523
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| LogP |
10.76
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
9
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| Heavy Atom Count |
31
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| Complexity |
654
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| Defined Atom Stereocenter Count |
1
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| SMILES |
CC(=CCC/C(=C/CC/C(=C/CC[C@]1(C)CCC2=C(C)C(=C(C)C(=C2O1)C)O)/C)/C)C
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| InChi Key |
RZFHLOLGZPDCHJ-XZXLULOTSA-N
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| InChi Code |
InChI=1S/C29H44O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h12,14,16,30H,9-11,13,15,17-19H2,1-8H3/b21-14+,22-16+/t29-/m1/s1
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| Chemical Name |
(2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~235.48 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.89 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.89 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3548 mL | 11.7741 mL | 23.5483 mL | |
| 5 mM | 0.4710 mL | 2.3548 mL | 4.7097 mL | |
| 10 mM | 0.2355 mL | 1.1774 mL | 2.3548 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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