| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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| ln Vivo |
Rats exposed to ABT-418 hydrochloride (125.66 μg/kg; intraperitoneal) spend a notably longer amount of time in the raised plus maze's open arms [1]. ABT-418 (125.66 μg/kg; intraperitoneal injection) administered acutely also lessens the anxiolytic effects of stopping long-term (-)-nicotine therapy [1]. Animal models of ADHD can benefit from ABT-418 hydrochloride (0.6 mg/kg; intraperitoneal injection; daily; for two weeks) in terms of improved spatial memory [2]. The expression of the hippocampus α4 subunit and cortical α4 and β2 nAChR subunits is markedly increased by ABT-418 hydrochloride [2].
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|---|---|
| Animal Protocol |
Animal/Disease Models: Male SHR (4-5 weeks old), attention deficit hyperactivity disorder (ADHD) model [2]
Doses: 0.6 mg/kg Route of Administration: intraperitoneal (ip) injection; one time/day; two-week effect: spatial memory is effectively improved. |
| References |
| Molecular Formula |
C₉H₁₅CLN₂O
|
|---|---|
| Molecular Weight |
202.68
|
| Exact Mass |
202.087
|
| CAS # |
147388-83-8
|
| PubChem CID |
10375597
|
| Appearance |
Light brown to brown solid powder
|
| Boiling Point |
249.2ºC at 760 mmHg
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| Flash Point |
104.5ºC
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| Vapour Pressure |
0.0232mmHg at 25°C
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| LogP |
2.489
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
13
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| Complexity |
163
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| Defined Atom Stereocenter Count |
1
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| SMILES |
CC1=NOC(=C1)[C@@H]2CCCN2C.Cl
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| InChi Key |
VOXHERKWAIEJQF-QRPNPIFTSA-N
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| InChi Code |
InChI=1S/C9H14N2O.ClH/c1-7-6-9(12-10-7)8-4-3-5-11(8)2;/h6,8H,3-5H2,1-2H3;1H/t8-;/m0./s1
|
| Chemical Name |
3-methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,2-oxazole;hydrochloride
|
| Synonyms |
ABT418 HCl; ABT 418 HCl
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| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~11.9 mg/mL (~58.71 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (493.39 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.9339 mL | 24.6694 mL | 49.3389 mL | |
| 5 mM | 0.9868 mL | 4.9339 mL | 9.8678 mL | |
| 10 mM | 0.4934 mL | 2.4669 mL | 4.9339 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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