ABBV-744

Alias: ABBV744; ABBV 744; ABBV-744.
Cat No.:V4567 Purity: ≥98%
ABBV-744 (ABBV744) is a novel, potent and highlyBDII-selective BET bromodomaininhibitor with anticancer and anti-inflammatory activity.
ABBV-744 Chemical Structure CAS No.: 2138861-99-9
Product category: Epigenetic Reader Domain
This product is for research use only, not for human use. We do not sell to patients.
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

ABBV-744 (ABBV744) is a novel, potent and highly BDII-selective BET bromodomain inhibitor with anticancer and anti-inflammatory activity. As a BDII-selective BET bromodomain inhibitor, it is under investigation for the treatment of AML and metastic castration-resistant prostate cancer. It also has the potential to be used in the treatment of inflammatory diseases and AIDS.

Biological Activity I Assay Protocols (From Reference)
Targets

BET bromodomain[1]

ln Vitro
ABBV744 is a highly BDII-selective BET bromodomain inhibitor, used in the research of inflammatory diseases, cancer, and AIDS[1].
ln Vivo
In comparison to ABBV-075 [1], ABBV-744 (4.7 mg/kg; interfacial gavage; 28 days) shown comparable or superior anti-tumor effectiveness and retarded the formation of tumors. /kg; 14) has strong anti-tumor properties. By 20%, ABBV-744 (30 mg/kg) suppresses interference [1].
Animal Protocol
Animal/Disease Models: Mouse
Doses: 4.7 mg/kg (pharmacokinetic/PK/PK analysis) Dosing: po (oral gavage); 28-day
Experimental Results: compared with ABBV-075, caused tumor growth delay and demonstrated the same or better anti- tumor activity.

Animal/Disease Models: SD (SD (Sprague-Dawley)) rat
Doses: 30 mg/kg (pharmacokinetic/PK/PK analysis) Dosing time: 14 days
Experimental Results: Produced significant anti-tumor activity.
References
[1]. Faivre EJ, et al. Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer. Nature. 2020;578(7794):306-310.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C28H30FN3O4
Molecular Weight
491.5539
CAS #
2138861-99-9
SMILES
O=C(C(N1)=CC(C(C2=CC(C(C)(O)C)=CC=C2OC3=C(C)C=C(F)C=C3C)=CN4C)=C1C4=O)NCC
InChi Key
OEDSFMUSNZDJFD-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H30FN3O4/c1-7-30-26(33)22-13-20-21(14-32(6)27(34)24(20)31-22)19-12-17(28(4,5)35)8-9-23(19)36-25-15(2)10-18(29)11-16(25)3/h8-14,31,35H,7H2,1-6H3,(H,30,33)
Chemical Name
N-ethyl-4-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide
Synonyms
ABBV744; ABBV 744; ABBV-744.
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO : ~100 mg/mL (~203.44 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.0344 mL 10.1719 mL 20.3438 mL
5 mM 0.4069 mL 2.0344 mL 4.0688 mL
10 mM 0.2034 mL 1.0172 mL 2.0344 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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