Size | Price | Stock | Qty |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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Abacavir acetate (Prurisol; abacavir hydroxyacetate; KM-133) is a potent and orally bioactive inhibitor of IL-20 and PRINS used for the treatment of plaque psoriasis. It can reduce the proliferation rate of skin in psoriasis as an immune modulator, and thus can be used for treating inflammatory skin problems.
ln Vivo |
In mice, oral abacavir glycolate (10–20 mg/kg) once daily efficiently reduces psoriasis [2].
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Animal Protocol |
Animal/Disease Models: 6 to 8 weeks old male and female SCID (severe combined immunodeficient) mouse, implanted with psoriatic tissue [2]
Doses: 10 and 20 mg/kg Route of Administration: po (oral gavage); 10-20 mg/kg Primary Experimental Results:Reduction The concentration of PRINS and 1L-20 reduces the area of skin lesions. Shows better results than methotrexate in controlling psoriasis. |
References |
[1]. Guda A, et al. Investigational drugs in phase II clinical trials for moderate to severe plaque psoriasis - potential new treatments on the horizon. Expert Opin Investig Drugs. 2018 Nov;27(11):931-939.
[2]. Menon, et al. CARBOCYCLIC NUCLEOSIDES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS. WO/2013/103601/Al. |
Molecular Formula |
C16H20N6O3
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Molecular Weight |
344.37
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Exact Mass |
344.1597
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CAS # |
1446418-48-9
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Related CAS # |
136470-78-5;136777-48-5 (HCl);168146-84-7 (succinate);188062-50-2 (sulfate); 1446418-48-9 (hydroxyacetate); 384380-52-3 (caeboxylate);
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SMILES |
O=C(OC[C@@H]1C=C[C@H](N2C=NC3=C(NC4CC4)N=C(N)N=C23)C1)CO
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Chemical Name |
((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methyl 2-hydroxyacetate
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Synonyms |
PrurisolKM133 KM 133KM-133 Abacavir hydroxyacetateAbacavir acetate
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~290.39 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.26 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.26 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.9039 mL | 14.5193 mL | 29.0385 mL | |
5 mM | 0.5808 mL | 2.9039 mL | 5.8077 mL | |
10 mM | 0.2904 mL | 1.4519 mL | 2.9039 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.