| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
By using the vital dye staining assay, the methylxanthine derivative A802715's toxicity was assessed against two human melanoma lines, Be11 and MeWo, as well as two human squamous cell carcinoma cell lines, 4197 and 4451. A802715 is the most hazardous, with a TD50 of 0.9-1.1 mM. BrdU incorporation demonstrated that A802715 significantly increased radiation-induced suppression of S phase entry in p53 wt cells. A802715 either prolongs G2/M arrest or is ineffective based on the cell line's p53 status [1].
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| References |
| Molecular Formula |
C16H26N4O3
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|---|---|
| Molecular Weight |
322.41
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| Exact Mass |
322.2
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| CAS # |
107767-58-8
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| PubChem CID |
129959
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| Appearance |
White to off-white solid powder
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| Density |
1.22g/cm3
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| Boiling Point |
526.7ºC at 760 mmHg
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| Flash Point |
272.3ºC
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| Vapour Pressure |
6.4E-12mmHg at 25°C
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| Index of Refraction |
1.584
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| LogP |
1.247
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
23
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| Complexity |
455
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C(N1CCCCC(C)(O)C)N(C)C2=C(N(CCC)C=N2)C1=O
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| InChi Key |
SBKAARSDXHSHSM-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H26N4O3/c1-5-9-19-11-17-13-12(19)14(21)20(15(22)18(13)4)10-7-6-8-16(2,3)23/h11,23H,5-10H2,1-4H3
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| Chemical Name |
1H-Purine-2,6-dione, 3,7-dihydro-1-(5-hydroxy-5-methylhexyl)-3-methyl-7-propyl-
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| Synonyms |
A-802715 A802715A 802715
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~190 mg/mL (~589.33 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 7.5 mg/mL (23.26 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 75.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 7.5 mg/mL (23.26 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 75.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 7.5 mg/mL (23.26 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1016 mL | 15.5082 mL | 31.0164 mL | |
| 5 mM | 0.6203 mL | 3.1016 mL | 6.2033 mL | |
| 10 mM | 0.3102 mL | 1.5508 mL | 3.1016 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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