| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
| Targets |
Human Endogenous Metabolite
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|---|---|
| References | |
| Additional Infomation |
Phosphonoacetic acid belongs to the phosphonate class of compounds, in which the hydrogen atom bonded to phosphorus is replaced by a carboxymethyl group. It possesses antiviral activity and is an inhibitor of EC 2.7.7.7 (DNA-directed DNA polymerase). It is a monocarboxylic acid belonging to the phosphonate class. Its function is related to both phosphonates and acetic acid. It is the conjugate acid of phosphonoacetic acid (2-). Phosphonoacetic acid is a metabolite of Escherichia coli (K12 strain, MG1655 strain). Sodium phosphonate is the sodium salt preparation of phosphonoacetic acid, active against herpes simplex virus and other members of the herpesvirus family. Ammonium phosphide inhibits viral DNA polymerase, thereby inhibiting viral DNA synthesis. Phosphonoacetic acid is an antiviral drug effective against herpes simplex virus and other members of the herpesvirus family. Phosphonoacetic acid inhibits viral DNA polymerase, thereby inhibiting viral DNA synthesis. A simple organophosphorus compound that inhibits DNA polymerase, especially effective against viruses, and is used as an antiviral drug.
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| Molecular Formula |
C2H5O5P
|
|---|---|
| Molecular Weight |
140.03
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| Exact Mass |
139.987
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| CAS # |
4408-78-0
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| PubChem CID |
546
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| Appearance |
White to off-white solid powder
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| Density |
1.858g/cm3
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| Boiling Point |
490.2ºC at 760mmHg
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| Melting Point |
143-146 °C(lit.)
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| LogP |
-2
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
8
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| Complexity |
133
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
XUYJLQHKOGNDPB-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7)
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| Chemical Name |
2-phosphonoacetic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : 260 mg/mL (1856.74 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (714.13 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.1413 mL | 35.7066 mL | 71.4133 mL | |
| 5 mM | 1.4283 mL | 7.1413 mL | 14.2827 mL | |
| 10 mM | 0.7141 mL | 3.5707 mL | 7.1413 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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