| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
| Targets |
Myristoyl glutamic acid sodium targets bacterial cells, exhibiting slight antibacterial functions. Its primary mechanism of action as a surfactant involves reducing surface tension, which aids in the removal of dirt and oil from the skin. Its slight antibacterial properties likely result from its ability to disrupt bacterial cell membranes.
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|---|---|
| ln Vitro |
In vitro, Myristoyl glutamic acid sodium demonstrates mild antibacterial properties. Its activity is typically assessed in antimicrobial susceptibility tests against various bacterial strains. Its surfactant properties are evaluated by measuring its ability to reduce surface tension and its foaming capacity. It is a mild cleanser and is used in cosmetic formulations.
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| ln Vivo |
In vivo, Myristoyl glutamic acid sodium is used in cosmetic and personal care products for its cleansing properties. Its mild cleaning ability and slight antibacterial functions make it suitable for use in facial cleansers and other skincare products. It is considered safe for topical application.
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| Enzyme Assay |
For surfactant activity testing, Myristoyl glutamic acid sodium is evaluated for its ability to reduce surface tension and its foaming properties. These assays measure the compound's effectiveness as a cleansing agent. Its mild antibacterial properties are assessed using standard antimicrobial susceptibility testing methods.
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| Cell Assay |
For cellular studies, bacterial cultures are treated with Myristoyl glutamic acid sodium at various concentrations. Bacterial growth inhibition is assessed by measuring optical density or by colony counting. The compound's mild antibacterial activity is confirmed by these assays.
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| Animal Protocol |
In vivo studies for Myristoyl glutamic acid sodium are conducted in the context of its use in cosmetic products. Safety and efficacy studies are performed on human volunteers or in animal models to assess its skin compatibility, cleansing efficiency, and lack of irritation.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Myristoyl glutamic acid sodium are not extensively detailed in the provided sources. It has a molecular weight of 379.47 and is typically stored at 4°C, sealed, away from moisture and light. As a surfactant used in topical applications, it is expected to have minimal systemic absorption.
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| Toxicity/Toxicokinetics |
Myristoyl glutamic acid sodium is considered safe for use in cosmetics and personal care products. It is a mild surfactant and is generally well-tolerated. Standard safety precautions should be followed when handling it. It is intended for research and cosmetic use only and is not for human therapeutic applications.
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| References | |
| Additional Infomation |
Myristoyl glutamic acid sodium is an amino acid surfactant with a molecular formula of C19H34NNaO5 and a molecular weight of 379.47. It has mild cleaning ability, foaming properties, and slight antibacterial functions. It is a common ingredient in cosmetics and face creams. This research compound is for laboratory use only and has not been approved for clinical applications.
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| Molecular Formula |
C19H34NNAO5
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|---|---|
| Molecular Weight |
379.47
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| Exact Mass |
379.233
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| CAS # |
38517-37-2
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| PubChem CID |
23682081
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| Appearance |
Typically exists as solid at room temperature
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| LogP |
3.177
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
17
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| Heavy Atom Count |
26
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| Complexity |
390
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| Defined Atom Stereocenter Count |
1
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| SMILES |
[Na+].CCCCCCCCCCCCCC(N[C@H](C([O-])=O)CCC(=O)O)=O
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| InChi Key |
ZNYIJXQYUNSKDX-NTISSMGPSA-M
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| InChi Code |
InChI=1S/C19H35NO5.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-17(21)20-16(19(24)25)14-15-18(22)23;/h16H,2-15H2,1H3,(H,20,21)(H,22,23)(H,24,25);/q;+1/p-1/t16-;/m0./s1
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| Chemical Name |
sodium;(2S)-5-hydroxy-5-oxo-2-(tetradecanoylamino)pentanoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : 2.5 mg/mL (6.59 mM)
DMF : < 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.25 mg/mL (0.66 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 2.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.25 mg/mL (0.66 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 2.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 0.25 mg/mL (0.66 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6353 mL | 13.1763 mL | 26.3525 mL | |
| 5 mM | 0.5271 mL | 2.6353 mL | 5.2705 mL | |
| 10 mM | 0.2635 mL | 1.3176 mL | 2.6353 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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