| Size | Price | |
|---|---|---|
| Other Sizes |
| ln Vitro |
DL-Pyroglutamic acid results 50 and 100%, respectively, inactivation of the antigen at 0.01-0.025% and 0.025-0.05%[1]. According to Druce and Bradford, DL-pyroglutamic acid may be a glutamate antagonist since it inhibits the glutamate miniature-end-plate potential in locust muscle [2].
|
|---|---|
| ln Vivo |
DL-Pyroglutamic acid (0.775 mM/L) cobalt implantation in the sensorimotor cerebral cortex completely eliminates the myoclonic jerks and EEG spikes in rats model of epilepsy[2].
|
| References | |
| Additional Infomation |
5-oxoproline is an oxoproline having the oxo group placed at the 5-position. It is an intermediate metabolite in the glutathione cycle. It has a role as a human metabolite. It is a pyrrolidinemonocarboxylic acid, a member of pyrrolidin-2-ones and an oxoproline. It is a conjugate acid of a 5-oxoprolinate.
DL-Pyroglutamic acid has been reported in Drosophila melanogaster, Mycoplasma gallisepticum, and other organisms with data available. A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism. |
| Molecular Formula |
C5H7NO3
|
|---|---|
| Molecular Weight |
129.11
|
| Exact Mass |
129.042
|
| CAS # |
149-87-1
|
| Related CAS # |
DL-Pyroglutamic acid-d5;352431-30-2
|
| PubChem CID |
499
|
| Appearance |
White to off-white solid powder
|
| Density |
1.4±0.1 g/cm3
|
| Boiling Point |
453.1±38.0 °C at 760 mmHg
|
| Melting Point |
180-185ºC
|
| Flash Point |
227.8±26.8 °C
|
| Vapour Pressure |
0.0±2.4 mmHg at 25°C
|
| Index of Refraction |
1.512
|
| LogP |
-2.39
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
9
|
| Complexity |
154
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
ODHCTXKNWHHXJC-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)
|
| Chemical Name |
5-oxopyrrolidine-2-carboxylic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : 100 mg/mL (774.53 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (19.36 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.7453 mL | 38.7267 mL | 77.4533 mL | |
| 5 mM | 1.5491 mL | 7.7453 mL | 15.4907 mL | |
| 10 mM | 0.7745 mL | 3.8727 mL | 7.7453 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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