| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Benzylurea does not have a well-defined specific biological target. As a urea derivative, it may interact with various biological targets depending on its chemical modifications. The compound is primarily used as a chemical intermediate for the synthesis of other compounds with potential biological activities.
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|---|---|
| ln Vitro |
Benzylurea does not exhibit significant direct pharmacological activity. Its utility is in its role as a chemical intermediate for the synthesis of other compounds. The compound's reactivity and stability make it suitable for various chemical transformations.
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| ln Vivo |
In vivo activity is not applicable to benzylurea as it is primarily a chemical intermediate rather than a therapeutic agent. The compound is not intended for administration to living organisms.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays are not performed for benzylurea, as it is a chemical intermediate rather than a pharmacologically active compound. Its characterization involves chemical analysis methods such as HPLC, NMR, and mass spectrometry.
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| Cell Assay |
In vitro cellular assays are not applicable to benzylurea. The compound is used in chemical synthesis reactions for the production of other compounds, which can subsequently be tested for biological activity.
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| Animal Protocol |
In vivo animal experiments are not applicable to benzylurea. The compound is a research chemical used in synthesis and is not intended for in vivo administration.
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| ADME/Pharmacokinetics |
Pharmacokinetic data are not applicable to benzylurea as it is a chemical intermediate, not a therapeutic agent. The compound is not intended for systemic administration.
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| Toxicity/Toxicokinetics |
Benzylurea is not intended for human therapeutic use, and toxicological data are not applicable as it is a research chemical. Standard laboratory safety precautions should be followed when handling this compound.
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| References | |
| Additional Infomation |
Benzylurea (CAS#: 538-32-9) has the molecular formula C8H10N2O and a molecular weight of 150.18. It is a urea derivative used as a chemical intermediate and in research applications. It is for research use only.
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| Molecular Formula |
C8H10N2O
|
|---|---|
| Molecular Weight |
150.18
|
| Exact Mass |
150.079
|
| CAS # |
538-32-9
|
| PubChem CID |
10853
|
| Appearance |
White to off-white solid powder
|
| Density |
1.138g/cm3
|
| Boiling Point |
282.9ºC at 760mmHg
|
| Melting Point |
149-151 °C(lit.)
|
| Flash Point |
124.9ºC
|
| Index of Refraction |
1.565
|
| LogP |
1.946
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
11
|
| Complexity |
130
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
RJNJWHFSKNJCTB-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C8H10N2O/c9-8(11)10-6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,9,10,11)
|
| Chemical Name |
benzylurea
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : 100 mg/mL (665.87 mM)
Ethanol : 50 mg/mL (332.93 mM) H2O : 3.33 mg/mL (22.17 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5 mg/mL (33.29 mM) (saturation unknown) in 10% EtOH + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear EtOH stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 5 mg/mL (33.29 mM) (saturation unknown) in 10% EtOH + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear EtOH stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 5 mg/mL (33.29 mM) (saturation unknown) in 10% EtOH + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.6587 mL | 33.2934 mL | 66.5868 mL | |
| 5 mM | 1.3317 mL | 6.6587 mL | 13.3174 mL | |
| 10 mM | 0.6659 mL | 3.3293 mL | 6.6587 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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