| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
AMOZ does not have a therapeutic target as it is a metabolite and marker compound, not a pharmacologically active agent. Its use is in analytical chemistry for the detection of nitrofuran antibiotic residues in food products.
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|---|---|
| ln Vitro |
AMOZ does not exhibit pharmacological activity. Its utility is in analytical methods for the detection of nitrofuran antibiotic residues. The compound is used as a reference standard in food safety testing.
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| ln Vivo |
AMOZ is not used as a therapeutic agent and does not exhibit in vivo activity. It is used as a marker in food safety testing to detect illegal antibiotic use in food-producing animals.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays are not performed for AMOZ, as it is an analytical standard used for residue detection. Its characterization involves analytical method validation, including assessment of its chromatographic behavior and mass spectrometric response.
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| Cell Assay |
In vitro cellular assays are not applicable to AMOZ, as it is an analytical standard used for quantification purposes. The compound is used as a reference standard in food safety testing.
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| Animal Protocol |
In vivo animal experiments for AMOZ are not typically performed, as it is a metabolite marker for food safety testing. The compound is detected in animal tissues as a residue of furaltadone administration.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for AMOZ are related to its formation as a metabolite of furaltadone. The compound is used as a marker for the detection of furaltadone residues in food-producing animals.
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| Toxicity/Toxicokinetics |
Toxicological data for AMOZ are related to its role as a nitrofuran metabolite. Nitrofurans are banned in food-producing animals in many countries due to their potential carcinogenicity. The compound is for research use only.
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| References |
[1]. UmapornPimpitak, et al. Development of a monoclonal antibody-based enzyme-linked immunosorbent assay for detection of the furaltadone metabolite, AMOZ, in fortified shrimp samples. Food Chemistry. Volume 116, Issue 3, 1 October 2009, Pages 785-791.
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| Additional Infomation |
3-Amino-5-morpholinomethyl-2-oxazolidinone belongs to the oxazolidinone class of compounds. Its structure is 3-amino-1,3-oxazolidin-2-one with a morpholino-4-ylmethyl group substituted at the 5-position. It is a metabolite of furazolidone, a broad-spectrum antibacterial drug that was once widely used as a feed additive for livestock, poultry, and aquaculture. It is a metabolite of exogenous substances, as well as exogenous substances in marine organisms. It belongs to the oxazolidinone class and is also a morpholino group of compounds.
AMOZ (3-Amino-5-morpholinomethyl-2-oxazolidone) (CAS#: 43056-63-9) has the molecular formula C8H15N3O3 and a molecular weight of 201.23 g/mol. It is a metabolite of the nitrofuran antibiotic furaltadone and is used as a marker for nitrofuran residue detection. |
| Molecular Formula |
C8H15N3O3
|
|---|---|
| Molecular Weight |
201.22
|
| Exact Mass |
201.111
|
| CAS # |
43056-63-9
|
| PubChem CID |
3016406
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| Appearance |
Off-white to light yellow solid powder
|
| Density |
1.281g/cm3
|
| Boiling Point |
315.8ºC at 760mmHg
|
| Melting Point |
115-120ºC
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| Flash Point |
144.8ºC
|
| Index of Refraction |
1.536
|
| LogP |
-1.1
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
14
|
| Complexity |
218
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O=C1OC(CN2CCOCC2)CN1N
|
| InChi Key |
TVHAMVOINIHMEX-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C8H15N3O3/c9-11-6-7(14-8(11)12)5-10-1-3-13-4-2-10/h7H,1-6,9H2
|
| Chemical Name |
3-amino-5-(morpholin-4-ylmethyl)-1,3-oxazolidin-2-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~496.97 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (12.42 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (12.42 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (12.42 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.9697 mL | 24.8484 mL | 49.6968 mL | |
| 5 mM | 0.9939 mL | 4.9697 mL | 9.9394 mL | |
| 10 mM | 0.4970 mL | 2.4848 mL | 4.9697 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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