| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| Other Sizes |
| Targets |
7-Methoxy-4-methyl-coumarin-8-ol does not have a well-defined specific pharmacological target. As a coumarin derivative, it may interact with various cellular targets involved in oxidative stress and inflammation. It is often studied for its therapeutic applications in preventing oxidative stress-related diseases. Derivatives have been tested for anticancer activity against HepG2 cells.
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|---|---|
| ln Vitro |
In vitro, 7-Methoxy-4-methyl-coumarin-8-ol is a coumarin derivative isolated from sour orange. Derivatives of 8-Hydroxy-7-methoxy-4-methyl-coumarin have been tested for anticancer activity against HepG2 cells. It is studied for its therapeutic applications in preventing oxidative stress-related diseases and as a natural bioactive agent in cosmetic formulations.
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| ln Vivo |
In vivo data for 7-Methoxy-4-methyl-coumarin-8-ol are limited in the available literature. As a coumarin derivative, it may have potential for therapeutic applications in oxidative stress-related diseases. Further in vivo studies are needed to evaluate its efficacy and safety.
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| Enzyme Assay |
7-Methoxy-4-methyl-coumarin-8-ol's biological activities can be characterized using various in vitro assays. Its antioxidant activity can be assessed using free radical scavenging assays. Its anticancer activity can be evaluated using cell viability assays in cancer cell lines such as HepG2.
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| Cell Assay |
In vitro cell experiments with 7-Methoxy-4-methyl-coumarin-8-ol involve treating cancer cells, such as HepG2, with the compound and assessing cell viability and apoptosis. The compound's antioxidant effects can be studied in cells exposed to oxidative stress.
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| Animal Protocol |
In vivo animal studies with 7-Methoxy-4-methyl-coumarin-8-ol have not been extensively reported in the available literature. The compound is a natural product from sour orange. Further studies are needed to evaluate its in vivo effects.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 7-Methoxy-4-methyl-coumarin-8-ol are not available in the searched literature. As a small molecule with a molecular weight of 206.19 g/mol, the compound may have reasonable oral bioavailability.
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| Toxicity/Toxicokinetics |
7-Methoxy-4-methyl-coumarin-8-ol is considered safe for research use at typical concentrations. As a natural product, it is generally considered to have a favorable safety profile. As a research compound, it is intended for laboratory use only and not for human consumption.
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| References | |
| Additional Infomation |
7-Methoxy-4-methyl-coumarin-8-ol has a molecular formula of C₁₁H₁₀O₄ and a molecular weight of 206.19 g/mol. Purity is typically >98%. It is a coumarin derivative isolated from sour orange (Citrus aurantium). It is studied for its therapeutic applications in preventing oxidative stress-related diseases and as a natural bioactive agent.
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| Molecular Formula |
C11H10O4
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|---|---|
| Molecular Weight |
206.1947
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| Exact Mass |
206.057
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| CAS # |
22084-94-2
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| PubChem CID |
596086
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| Appearance |
White to off-white solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
383.2±42.0 °C at 760 mmHg
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| Flash Point |
154.4±21.4 °C
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| Vapour Pressure |
0.0±0.9 mmHg at 25°C
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| Index of Refraction |
1.588
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| LogP |
1.61
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
15
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| Complexity |
297
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
HHSJFOILNWMNFO-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11H10O4/c1-6-5-9(12)15-11-7(6)3-4-8(14-2)10(11)13/h3-5,13H,1-2H3
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| Chemical Name |
8-hydroxy-7-methoxy-4-methylchromen-2-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~484.99 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (12.12 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8499 mL | 24.2495 mL | 48.4990 mL | |
| 5 mM | 0.9700 mL | 4.8499 mL | 9.6998 mL | |
| 10 mM | 0.4850 mL | 2.4249 mL | 4.8499 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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