| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 100mg | |||
| Other Sizes |
| Targets |
Not well characterized; potential targets include GABA receptors, serotonin receptors, and other central nervous system targets involved in sleep and anxiety.
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|---|---|
| ln Vitro |
In vitro, 6‴-Feruloylspinosin may exhibit sedative and anxiolytic effects through modulation of neurotransmitter systems (e.g., GABAergic or serotonergic pathways). It may also show antioxidant and neuroprotective activities. Quantitative in vitro activity data is not detailed in publicly available sources.
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| ln Vivo |
In vivo, 6‴-Feruloylspinosin has been studied for its sedative and hypnotic effects in animal models. It may increase sleep duration and reduce anxiety-like behaviors. Detailed dose-response and pharmacokinetic data are limited in publicly available literature.
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| Enzyme Assay |
No specific cell-free receptor binding assay protocol is detailed for 6‴-Feruloylspinosin. For flavonoid C-glycosides, typical cell-free assays include receptor binding studies using radioligands for GABA-A, 5-HT1A, or other CNS targets.
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| Cell Assay |
Cellular activity is assessed in neuronal cell lines or primary neurons. Cells are treated with 6‴-Feruloylspinosin, and endpoints include neurotransmitter release measurement, calcium imaging, and receptor activation assays (e.g., cAMP or IP3 accumulation).
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| Animal Protocol |
In vivo efficacy is evaluated in rodent models of insomnia or anxiety. 6‴-Feruloylspinosin is administered via oral gavage or intraperitoneal injection. Endpoints include sleep parameters (EEG, duration), behavioral tests (elevated plus maze, open field test), and neurotransmitter levels in brain tissue.
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| ADME/Pharmacokinetics |
Molecular weight: approximately 784.75; molecular formula: C37H40O19 (typical for feruloyl spinosin). Solubility: soluble in DMSO, methanol; poorly soluble in water. Storage: typical for flavonoids (desiccated, protected from light, -20°C).
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| Toxicity/Toxicokinetics |
No detailed toxicity data is publicly available. As a natural flavonoid from an edible plant, it is likely to have low toxicity, but standard toxicological studies would be required for drug development.
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| References | |
| Additional Infomation |
According to reports, jujubes and dates contain 6'''-feruloylinosine, and there is available data.
6‴-Feruloylspinosin is a research-grade compound, not approved for therapeutic use. It is primarily used for pharmacological research in neuroscience, sleep, and anxiety. No clinical trials have been reported. It is a natural product from Ziziphus jujuba used in traditional medicine for insomnia. |
| Molecular Formula |
C38H40O18
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|---|---|
| Molecular Weight |
784.7134
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| Exact Mass |
784.221
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| CAS # |
77690-92-7
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| PubChem CID |
21597353
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| Appearance |
Light yellow to yellow solid powder
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| Density |
1.6±0.1 g/cm3
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| Boiling Point |
1029.8±65.0 °C at 760 mmHg
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| Flash Point |
317.7±27.8 °C
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| Vapour Pressure |
0.0±0.3 mmHg at 25°C
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| Index of Refraction |
1.721
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| LogP |
3.37
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| Hydrogen Bond Donor Count |
9
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| Hydrogen Bond Acceptor Count |
18
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| Rotatable Bond Count |
12
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| Heavy Atom Count |
56
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| Complexity |
1390
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| Defined Atom Stereocenter Count |
10
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| SMILES |
COC1=C(C=CC(=C1)/C=C/C(=O)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)O[C@@H]3[C@H]([C@@H]([C@H](O[C@H]3C4=C(C=C5C(=C4O)C(=O)C=C(O5)C6=CC=C(C=C6)O)OC)CO)O)O)O)O)O)O
|
| InChi Key |
WZAXZHIVHPRTIU-IHIXZLSHSA-N
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| InChi Code |
InChI=1S/C38H40O18/c1-50-22-11-16(3-9-19(22)41)4-10-27(43)52-15-26-31(45)33(47)35(49)38(55-26)56-37-34(48)30(44)25(14-39)54-36(37)29-23(51-2)13-24-28(32(29)46)20(42)12-21(53-24)17-5-7-18(40)8-6-17/h3-13,25-26,30-31,33-41,44-49H,14-15H2,1-2H3/b10-4+/t25-,26-,30-,31-,33+,34+,35-,36+,37-,38+/m1/s1
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| Chemical Name |
[(2R,3S,4S,5R,6S)-6-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-2-[5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4-oxochromen-6-yl]-6-(hydroxymethyl)oxan-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~127.44 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (3.19 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (3.19 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (3.19 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.2744 mL | 6.3718 mL | 12.7436 mL | |
| 5 mM | 0.2549 mL | 1.2744 mL | 2.5487 mL | |
| 10 mM | 0.1274 mL | 0.6372 mL | 1.2744 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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