| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| 250mg | |||
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| Other Sizes |
| Targets |
6'-Sialyllactose sodium does not have a specific therapeutic target but functions as a bioactive milk oligosaccharide. It may interact with various receptors and modulate immune responses. The compound's mechanism of action involves reducing the internalization of Pseudomonas aeruginosa in human lung cells. It is also involved in promoting infant health, including gastrointestinal health and neurodevelopment.
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| ln Vitro |
6'-Sialyllactose sodium reduces the internalization of Pseudomonas aeruginosa in human lung cells. As a major milk oligosaccharide, it plays a role in promoting infant health, including gastrointestinal health and neurodevelopment. The compound's specific biological activities and potency values are not extensively documented in the public domain. It is used in research on milk oligosaccharides and infant health.
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| ln Vivo |
In vivo, 6'-sialyllactose sodium is a major milk oligosaccharide that plays a role in promoting infant health. It has been shown to reduce the internalization of Pseudomonas aeruginosa in human lung cells. The compound may have potential for preventing infections and promoting gastrointestinal health. Specific in vivo efficacy studies in animal models are not extensively documented.
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| Enzyme Assay |
The in vitro assay for 6'-sialyllactose sodium typically involves testing its effects on bacterial internalization. Human lung cells are treated with varying concentrations of the compound (typically 0.1-100 µM) and then exposed to Pseudomonas aeruginosa. Bacterial internalization is assessed by gentamicin protection assays or fluorescence microscopy. The compound is dissolved in PBS or cell culture medium.
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| Cell Assay |
In vitro cellular assays for 6'-sialyllactose sodium typically involve treating human lung cells or other cell types with the compound at concentrations ranging from 0.1 to 100 µM for various time periods. Cell viability is assessed using MTT or other standard assays. The compound's effects on bacterial internalization and immune responses are evaluated. The compound is dissolved in PBS or cell culture medium.
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| Animal Protocol |
In vivo animal studies for 6'-sialyllactose sodium are not extensively documented. For potential in vivo applications, the compound could be administered to mice or rats via oral gavage or dietary supplementation at doses determined from preliminary studies. Infection models or gastrointestinal health models could be used to evaluate efficacy. The compound's pharmacokinetics and pharmacodynamics would be evaluated in these models.
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| ADME/Pharmacokinetics |
6'-Sialyllactose sodium has a molecular weight of 655.53 g/mol and formula C23H38NNaO19. Purity is ≥98%. It is soluble in DMSO (5 mg/ml) and PBS (pH 7.2, 10 mg/ml). Recommended storage is at -20°C. The compound is a crystalline solid. Detailed PK parameters would require experimental determination.
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| Toxicity/Toxicokinetics |
6'-Sialyllactose sodium is intended for research use only and is not approved for human therapeutic applications. As a naturally occurring milk oligosaccharide, it is generally considered to have low toxicity. Appropriate safety precautions should be taken when handling. Standard toxicity assessments would include acute toxicity and repeated-dose toxicity studies if required for specific applications.
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| Additional Infomation |
6'-Sialyllactose sodium (CAS 157574-76-0) is a major milk oligosaccharide with a molecular weight of 655.53 g/mol and formula C23H38NNaO19. It consists of N-acetylneuraminic acid linked to lactose at the 6 position. The compound reduces the internalization of Pseudomonas aeruginosa in human lung cells and promotes infant health. It is also known as 6'-N-Acetylneuraminyl-D-lactose and 6'-唾液乳糖钠盐. The compound is not approved for clinical use.
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| Molecular Formula |
C23H38NNAO19
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|---|---|
| Molecular Weight |
655.532900333405
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| Exact Mass |
655.193
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| CAS # |
157574-76-0
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| PubChem CID |
132285181
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| Appearance |
Typically exists as solid at room temperature
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| Hydrogen Bond Donor Count |
12
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| Hydrogen Bond Acceptor Count |
19
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| Rotatable Bond Count |
15
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| Heavy Atom Count |
44
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| Complexity |
934
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| Defined Atom Stereocenter Count |
15
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| SMILES |
[Na+].O1C(C(=O)[O-])(CC(C(C1[C@H]([C@H](CO)O)O)NC(C)=O)O)OCC1C(C(C(C(OC2C(CO)OC(C(C2O)O)O)O1)O)O)O
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| InChi Key |
LJNVKOGOHXWREM-MZZLGFSDSA-M
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| InChi Code |
InChI=1S/C23H39NO19.Na/c1-7(28)24-13-8(29)2-23(22(38)39,43-20(13)15(34)10(31)4-26)40-6-12-16(35)17(36)18(37)21(41-12)42-19(11(32)5-27)14(33)9(30)3-25;/h3,8-21,26-27,29-37H,2,4-6H2,1H3,(H,24,28)(H,38,39);/q;+1/p-1/t8-,9-,10+,11+,12+,13+,14+,15+,16-,17-,18+,19+,20+,21-,23+;/m0./s1
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| Chemical Name |
sodium;(2R,4S,5R,6R)-5-acetamido-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxyoxan-2-yl]methoxy]oxane-2-carboxylate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~125 mg/mL (~190.69 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: 12.5 mg/mL (19.07 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.5255 mL | 7.6274 mL | 15.2548 mL | |
| 5 mM | 0.3051 mL | 1.5255 mL | 3.0510 mL | |
| 10 mM | 0.1525 mL | 0.7627 mL | 1.5255 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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