| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| Other Sizes |
| ADME/Pharmacokinetics |
The content of 6-O-Acetylglycitin was measured in steamed black soybeans and black soybean koji (fermented with Aspergillus awamori) during storage under various conditions. Its stability was found to be dependent on storage temperature, packaging (presence of deoxidant and/or desiccant), and the food matrix. [1]
In steamed black soybeans stored at 4°C for 120 days with deoxidant and desiccant, the residual content of 6-O-Acetylglycitin was 92.0% of its initial value. When stored without deoxidant and desiccant under the same temperature, the residual was 84.7%. [1] In steamed black soybeans stored at 25°C for 120 days with deoxidant and desiccant, the residual content of 6-O-Acetylglycitin was 89.2% of its initial value. When stored without deoxidant and desiccant under the same temperature, the residual was 85.0%. [1] In black soybean koji stored at 4°C for 120 days with deoxidant and desiccant, the residual content of 6-O-Acetylglycitin was 88.7% of its initial value. When stored without deoxidant and desiccant under the same temperature, the residual was 86.3%. [1] In black soybean koji stored at 25°C for 120 days with deoxidant and desiccant, the residual content of 6-O-Acetylglycitin was 86.4% of its initial value. When stored without deoxidant and desiccant under the same temperature, the residual was 83.1%. [1] |
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| References | |
| Additional Infomation |
Glycitein 7-(6-O-acetyl-β-D-glucoside) is a glycosyl isoflavone, a compound of Glycitein with an acetyl substituent at the 6-position of the glucose moiety. It is a plant metabolite. It is an acetate, glycosyl isoflavone, hydroxy isoflavone, methoxy isoflavone, monosaccharide derivative, β-D-glucoside, and O-acyl carbohydrate. Functionally, it is related to Glycitein.
6''-O-acetylGlycitein has been reported to exist in soybean (Glycine max) and the genus Glycine, but relevant data are still unclear. 6-O-Acetylglycitin is an acetyl glucoside isoflavone isomer found in black soybeans and black soybean products. It is one of the three acetyl glucosides examined in this study, along with acetyldaidzin and acetylgenistin. [1] The study suggests that the presence of a methoxy group at the 6-position of the aromatic ring in 6-O-Acetylglycitin (and similarly in glycitein and malonylglycitin) could result in lower bond dissociation energy, making it less stable compared to other respective isoflavone isomers (e.g., daidzin/acetyldaidzin or genistin/acetylgenistin) during storage. This may explain its generally lower residual content after storage compared to other acetyl glucosides under similar conditions. [1] |
| Molecular Formula |
C24H24O11
|
|---|---|
| Molecular Weight |
488.44
|
| Exact Mass |
488.132
|
| CAS # |
134859-96-4
|
| PubChem CID |
10228095
|
| Appearance |
White to off-white solid powder
|
| Density |
1.49g/cm3
|
| Boiling Point |
741.551ºC at 760 mmHg
|
| Melting Point |
155 - 157 °C
|
| Flash Point |
254.511ºC
|
| Vapour Pressure |
0mmHg at 25°C
|
| Index of Refraction |
1.639
|
| LogP |
0.923
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| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
11
|
| Rotatable Bond Count |
7
|
| Heavy Atom Count |
35
|
| Complexity |
792
|
| Defined Atom Stereocenter Count |
5
|
| SMILES |
CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)OC2=C(C=C3C(=C2)OC=C(C3=O)C4=CC=C(C=C4)O)OC)O)O)O
|
| InChi Key |
DUBPGEJGGVZKDD-PFKOEMKTSA-N
|
| InChi Code |
InChI=1S/C24H24O11/c1-11(25)32-10-19-21(28)22(29)23(30)24(35-19)34-18-8-16-14(7-17(18)31-2)20(27)15(9-33-16)12-3-5-13(26)6-4-12/h3-9,19,21-24,26,28-30H,10H2,1-2H3/t19-,21-,22+,23-,24-/m1/s1
|
| Chemical Name |
[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[3-(4-hydroxyphenyl)-6-methoxy-4-oxochromen-7-yl]oxyoxan-2-yl]methyl acetate
|
| Synonyms |
6 O Acetylglycitin 6OAcetylglycitin6-O-Acetylglycitin Glycitein 6'-O-Acetylglucoside
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~204.73 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.12 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.12 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (5.12 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0473 mL | 10.2367 mL | 20.4733 mL | |
| 5 mM | 0.4095 mL | 2.0473 mL | 4.0947 mL | |
| 10 mM | 0.2047 mL | 1.0237 mL | 2.0473 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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