| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| Other Sizes |
| Targets |
Natural flavone
Not well characterized; as a flavonoid, it may target various cellular pathways including antioxidant, anti-inflammatory, and enzyme inhibition pathways. Further target identification studies are needed. |
|---|---|
| ln Vitro |
Two new highly oxygenated flavones were isolated from Artemisia frigida. Their structures were determined by spectroscopic methods as 5,7,4′-trihydroxy-6,3′,5′-trimethoxyflavone and 5,7,3′-trihydroxy-6,4′,5′-trimethoxyflavone[1].
In vitro bioactivity data is limited. As a methylated flavone from Artemisia species, it may exhibit antioxidant, anti-inflammatory, or enzyme inhibitory activities typical of flavonoids. However, quantitative in vitro activity data (IC50 values) and specific bioactivity assays are not readily available in public literature. |
| ln Vivo |
No in vivo activity data is publicly available for this compound. As a natural flavonoid, it may exhibit systemic bioactivities if orally administered, but specific animal model studies have not been reported in the available literature.
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| Enzyme Assay |
No specific cell-free enzyme/receptor binding assay protocol is detailed for this compound. For flavonoid compounds, typical cell-free assays include antioxidant assays (DPPH, ABTS radical scavenging), enzyme inhibition assays (e.g., COX, LOX, α-glucosidase), and receptor binding assays using radioligands or SPR.
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| Cell Assay |
Cellular activity is typically assessed in standard cell lines (e.g., macrophages, cancer cells) for anti-inflammatory, antioxidant, or anticancer effects. Cells are treated with serial dilutions of the flavonoid, and endpoints include cytokine production (ELISA), reactive oxygen species measurement (fluorescent probes), or cell viability (MTT assay).
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| Animal Protocol |
No in vivo animal experimental protocol is publicly available. For flavonoid compounds, typical in vivo studies involve oral administration in rodent models of inflammation, oxidative stress, or metabolic disorders, with endpoints including biomarker analysis, histopathology, and organ function tests.
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| ADME/Pharmacokinetics |
Molecular weight: 360.31; molecular formula: C18H16O8. Purity: >98%. Appearance: powder. Storage: typical for flavonoids (desiccated, protected from light, -20°C).
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| Toxicity/Toxicokinetics |
No toxicity data is publicly available. As a natural flavonoid from edible Artemisia species, it is likely to have low toxicity, but standard toxicological studies would be required for drug development.
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| References | |
| Additional Infomation |
5,7,3'-Trihydroxy-6,4',5'-Trimethoxyflavone is an ether compound belonging to the flavonoid class. It has been reported to exist in gardenia (Gardenia sootepensis), Artemisia herba-alba, and other organisms with relevant data.
5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone is a research-grade compound, not approved for therapeutic use. It is primarily used as a reference standard for analytical chemistry and for pharmacological research on flavonoids. No clinical trials have been reported. It is isolated from Artemisia frigida and Artemisia argyi. |
| Molecular Formula |
C18H16O8
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|---|---|
| Molecular Weight |
360.3148
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| Exact Mass |
360.085
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| CAS # |
78417-26-2
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| PubChem CID |
5496475
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| Appearance |
Off-white to light yellow solid powder
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| Density |
1.461±0.06 g/cm3(Predicted)
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| Boiling Point |
646.1±55.0 °C(Predicted)
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| Source |
Gardenia sootepensis; Artemisia frigida ; Artemisia herba-alba
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| LogP |
2.602
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
26
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| Complexity |
549
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| Defined Atom Stereocenter Count |
0
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| SMILES |
COC1=CC(=CC(=C1OC)O)C2=CC(=O)C3=C(O2)C=C(C(=C3O)OC)O
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| InChi Key |
PMBOOVZSTMWOFS-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C18H16O8/c1-23-14-5-8(4-10(20)17(14)24-2)12-6-9(19)15-13(26-12)7-11(21)18(25-3)16(15)22/h4-7,20-22H,1-3H3
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| Chemical Name |
5,7-dihydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxychromen-4-one
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| Synonyms |
5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone; 78417-26-2; 5,7-dihydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxychromen-4-one; 5,?7,?3'-?Trihydroxy-?6,?4',?5'-?trimethoxyflavone; 5,7-Dihydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4H-chromen-4-one; CHEBI:228841;
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~277.54 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.94 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7754 mL | 13.8769 mL | 27.7539 mL | |
| 5 mM | 0.5551 mL | 2.7754 mL | 5.5508 mL | |
| 10 mM | 0.2775 mL | 1.3877 mL | 2.7754 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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