| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg | |||
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| Other Sizes |
| Targets |
5-Methoxytryptophol targets pathways involved in bone metabolism and potentially other physiological processes. As an indole compound and a product of melatonin metabolism, it may interact with melatonin receptors or other targets. Its role in bone metabolism suggests it may influence osteoblast or osteoclast activity. However, its exact mechanism of action is not fully elucidated. It is an endogenous compound that may have biological activity.
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| ln Vitro |
In vitro studies on 5-Methoxytryptophol are limited. As a natural indole and a product of melatonin metabolism, it may have biological activity. Its role in bone metabolism suggests potential effects on bone cells. However, detailed in vitro potency data are not extensively documented in the available literature. Further studies are needed to characterize its biological activities.
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| ln Vivo |
In vivo, 5-Methoxytryptophol is a naturally occurring compound produced by the pineal gland. It is a product of melatonin metabolism and may be biologically active. It plays a significant role in bone metabolism. However, specific in vivo efficacy data are not detailed in the available literature. The compound is not used as a therapeutic agent.
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| Enzyme Assay |
In vitro non-cell assays for 5-Methoxytryptophol are not standard, as its mechanism is not fully elucidated. Its antioxidant activity, if any, could be measured using cell-free assays such as DPPH or ABTS. Its binding to melatonin receptors could be assessed using radioligand binding studies.
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| Cell Assay |
In vitro cell-based assays for 5-Methoxytryptophol would use bone cell lines, such as osteoblasts or osteoclasts, to study its effects on bone metabolism. Cells are treated with varying concentrations of the compound, and parameters such as cell proliferation, differentiation, and bone matrix production are assessed. However, specific published data are limited.
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| Animal Protocol |
In vivo animal studies for 5-Methoxytryptophol would likely employ models of bone metabolism, such as ovariectomized rats (a model of osteoporosis). The compound would be administered, and parameters such as bone mineral density, bone turnover markers, and bone histomorphometry would be assessed. However, specific published data are limited.
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| ADME/Pharmacokinetics |
5-Methoxytryptophol has a molecular weight of 191.23 g/mol and a molecular formula of C₁₁H₁₃NO₂. It is also known as 5-MTOH and 5-MTX. It is a naturally occurring indole compound produced by the pineal gland. The compound should be stored under appropriate conditions, typically at -20°C, protected from light and moisture.
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| Toxicity/Toxicokinetics |
The toxicity profile of 5-Methoxytryptophol has not been comprehensively evaluated in published studies. As an endogenous compound, it is generally considered to have low toxicity. However, its biological activity in bone metabolism suggests that it may have significant effects that require careful evaluation. The compound is classified as a research reagent and is not intended for human therapeutic use without further safety evaluation.
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| References |
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| Additional Infomation |
5-Methoxytryptophanol is a member of the indole class of compounds.
5-Methoxytryptophol is a naturally occurring indole compound produced by the pineal gland. It is a product of melatonin metabolism that plays a significant role in bone metabolism. Not approved for clinical use; intended for research purposes only. |
| Molecular Formula |
C11H13NO2
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|---|---|
| Molecular Weight |
191.22642
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| Exact Mass |
191.095
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| CAS # |
712-09-4
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| PubChem CID |
12835
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| Appearance |
Colorless to light yellow viscous liquid
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| Density |
1.224 g/cm3
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| Boiling Point |
393.9ºC at 760 mmHg
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| Flash Point |
192ºC
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| Index of Refraction |
1.64
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| LogP |
1.711
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
14
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| Complexity |
186
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| Defined Atom Stereocenter Count |
0
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| SMILES |
OCCC1=CNC2=C1C=C(OC)C=C2
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| InChi Key |
QLWKTGDEPLRFAT-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11H13NO2/c1-14-9-2-3-11-10(6-9)8(4-5-13)7-12-11/h2-3,6-7,12-13H,4-5H2,1H3
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| Chemical Name |
2-(5-methoxy-1H-indol-3-yl)ethanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~522.93 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (13.07 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (13.07 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.2293 mL | 26.1465 mL | 52.2931 mL | |
| 5 mM | 1.0459 mL | 5.2293 mL | 10.4586 mL | |
| 10 mM | 0.5229 mL | 2.6147 mL | 5.2293 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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