| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
| ln Vivo |
- 4',7-Di-O-methylnaringenin exhibited significant antinociceptive activity in the acetic acid-induced writhing test in mice. At intraperitoneal (i.p.) doses of 10, 20, and 40 mg/kg, it reduced the number of writhing responses by 32.6%, 58.1%, and 76.7%, respectively, compared to the control group. The ED50 value was calculated as 18.3 mg/kg [1]
- In the hot-plate test in mice, 4',7-Di-O-methylnaringenin (i.p. administration at 20 and 40 mg/kg) significantly increased the paw withdrawal latency (PWL) at 30, 60, 90, and 120 min post-administration. The maximum antinociceptive effect was observed at 60 min, with PWL values increased by 45.2% and 68.9% at 20 mg/kg and 40 mg/kg, respectively [1] |
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| Animal Protocol |
- Acetic acid-induced writhing test: Male Swiss mice (25–30 g) were randomly divided into control, positive control (morphine, 5 mg/kg i.p.), and 4',7-Di-O-methylnaringenin treatment groups (10, 20, 40 mg/kg i.p.). Thirty minutes after administration, mice were injected intraperitoneally with 0.6% acetic acid, and the number of writhing responses was counted for 20 minutes [1]
- Hot-plate test: Male Swiss mice (25–30 g) were pre-selected for paw withdrawal latency (PWL) between 5–10 seconds on a hot plate maintained at 55 ± 1°C. Mice were divided into control, positive control (morphine, 5 mg/kg i.p.), and 4',7-Di-O-methylnaringenin treatment groups (20, 40 mg/kg i.p.). PWL was measured at 0 (baseline), 30, 60, 90, and 120 min post-administration, with a cut-off time of 30 seconds to avoid tissue damage [1] |
| References | |
| Additional Infomation |
(2S)-5-hydroxy-4',7-dimethoxyflavanone is a 5-hydroxy-4',7-dimethoxyflavanone with the (S)-configuration. It is both a 5-hydroxy-4',7-dimethoxyflavanone and a (2S)-flavan-4-one. It is functionally related to (S)-naringin.
(S)-5-hydroxy-7-methoxy-2-(4-methoxyphenyl)somn-4-one has been reported in Vitex quinata, Sarcandra hainanensis and other organisms with relevant data. -4',7-di-O-methylnaringin is a flavonoid secondary metabolite isolated from wild and microscopic Renéalmia alpinia plants [1]. - 4',7-Di-O-methylnaringin showed comparable analgesic activity to the positive control morphine in the test model, indicating its potential as a natural analgesic [1]. - Renalmia alpinia is used in traditional ethnomedicine to treat pain-related diseases, and 4',7-Di-O-methylnaringin is one of the active ingredients that exerts this activity [1]. |
| Molecular Formula |
C17H16O5
|
|---|---|
| Molecular Weight |
300.3059
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| Exact Mass |
300.099
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| CAS # |
29424-96-2
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| PubChem CID |
14057196
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| Appearance |
White to off-white solid powder
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| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
524.4±50.0 °C at 760 mmHg
|
| Flash Point |
196.0±23.6 °C
|
| Vapour Pressure |
0.0±1.4 mmHg at 25°C
|
| Index of Refraction |
1.597
|
| LogP |
4.02
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
3
|
| Heavy Atom Count |
22
|
| Complexity |
391
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
COC1=CC=C(C=C1)[C@@H]2CC(=O)C3=C(C=C(C=C3O2)OC)O
|
| InChi Key |
CKEXCBVNKRHAMX-HNNXBMFYSA-N
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| InChi Code |
InChI=1S/C17H16O5/c1-20-11-5-3-10(4-6-11)15-9-14(19)17-13(18)7-12(21-2)8-16(17)22-15/h3-8,15,18H,9H2,1-2H3/t15-/m0/s1
|
| Chemical Name |
(2S)-5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-2,3-dihydrochromen-4-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~332.99 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.32 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.32 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3299 mL | 16.6495 mL | 33.2989 mL | |
| 5 mM | 0.6660 mL | 3.3299 mL | 6.6598 mL | |
| 10 mM | 0.3330 mL | 1.6649 mL | 3.3299 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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