| Size | Price | Stock | Qty |
|---|---|---|---|
| 5g |
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| Other Sizes |
| Targets |
This compound does not have a well‑defined pharmacological target as a drug. However, thiazole derivatives often target enzymes such as kinases, topoisomerases, or parasite enzymes. The compound itself has been used to synthesize novel HldE kinase inhibitors against Gram‑negative bacteria and potential antimalarial bisthiazolium analogs. It may also interact with copper ions, as graphene oxide modified with it selectively adsorbs Cu²⁺.
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|---|---|
| ln Vitro |
In vitro, 4‑methyl‑5‑thiazoleethanol exhibits antibacterial activity against certain wild‑type bacterial strains. It is a precursor for bioactive thiazoles that show antitumor and antifilarial effects. The compound itself has limited direct activity; most research focuses on its derivatives. It does not show significant cytotoxicity at concentrations used in flavor applications.
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| ln Vivo |
In vivo, it has been studied in a mouse model of non‑obese NAFLD, where it influenced intestinal flora composition and metabolite profiles. However, detailed pharmacological in vivo data are scarce. It is generally recognized as safe for food use, so it does not produce adverse effects at normal dietary levels.
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| Enzyme Assay |
Not applicable for enzyme/receptor binding assays. For flavor analysis, protocols involve extraction from food matrices and GC‑MS or HPLC analysis. For chemical synthesis, it is used as a building block in standard organic reactions. No specific biological assay protocol is established for the parent compound.
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| Cell Assay |
Cellular assays are not typically performed with this flavor compound. However, when testing its derivatives, standard cell viability (MTT), antimicrobial (MIC), and antimalarial (parasite growth inhibition) assays are employed. For the parent compound, no cellular activity is reported.
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| Animal Protocol |
In the NAFLD mouse study, male C57BL/6 mice were fed a high‑fat diet and administered the compound (dose not specified) for several weeks. Fecal samples were collected for 16S rRNA sequencing and metabolomic analysis. Body weight, liver histology, and serum parameters were measured. This is the only reported in vivo study.
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| ADME/Pharmacokinetics |
Pharmacokinetic data are not available for this compound. It is soluble in alcohol and has a characteristic odor. As a flavor substance, it is metabolized and excreted quickly. It is stable under normal storage.
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| Toxicity/Toxicokinetics |
Toxicity is low; it is listed in the FDA’s EAFUS (Everything Added to Food) inventory and is considered safe for use as a flavoring agent. No carcinogenic or mutagenic effects have been reported. Standard handling precautions apply.
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| References |
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| Additional Infomation |
5-(2-hydroxyethyl)-4-methylthiazole is a 1,3-thiazole compound in which a methyl group is substituted at the 4-position of the thiazole ring, and a 2-hydroxyethyl group is substituted at the 5-position. It is found in Saccharomyces cerevisiae, Escherichia coli, and humans. It is a primary alcohol belonging to the 1,3-thiazole class of compounds. Its function is similar to that of 5-(2-hydroxyethyl)-1,3-thiazole. It is derived from the hydride of thiazole. 5-(2-hydroxyethyl)-4-methylthiazole is a metabolite found or produced in Escherichia coli (K12, MG1655 strains). 4-Methyl-5-(2-hydroxyethyl)thiazole is a metabolite found or produced in Escherichia coli (K12, MG1655 strains). It has been reported that ginseng, Euglena gravidarum, and Saccharomyces cerevisiae all contain 4-methyl-5-thiazoleethanol, but relevant data are unclear. 5-(2-hydroxyethyl)-4-methylthiazole is a metabolite found or produced in Saccharomyces cerevisiae.
4‑Methyl‑5‑thiazoleethanol is a commercially available flavor chemical and intermediate. It is used in the preparation of various thiazole pharmaceuticals and agrochemicals. It has also been explored for environmental applications, such as copper ion adsorption. It is produced by synthetic routes and is available in bulk quantities. For research, it is supplied as a colorless to pale yellow liquid with purity >98%. Store in a cool, dry place. |
| Molecular Formula |
C6H9NOS
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|---|---|
| Molecular Weight |
143.2068
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| Exact Mass |
143.04
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| CAS # |
137-00-8
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| PubChem CID |
1136
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| Appearance |
Light yellow to yellow liquid
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
272.4±0.0 °C at 760 mmHg
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| Melting Point |
< 25 °C
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| Flash Point |
109.7±23.2 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
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| Index of Refraction |
1.564
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| LogP |
0.04
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
9
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| Complexity |
89.1
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| Defined Atom Stereocenter Count |
0
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| SMILES |
S1C([H])=NC(C([H])([H])[H])=C1C([H])([H])C([H])([H])O[H]
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| InChi Key |
BKAWJIRCKVUVED-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H9NOS/c1-5-6(2-3-8)9-4-7-5/h4,8H,2-3H2,1H3
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| Chemical Name |
2-(4-methyl-1,3-thiazol-5-yl)ethanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~698.32 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (17.46 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (17.46 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (17.46 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.9828 mL | 34.9138 mL | 69.8275 mL | |
| 5 mM | 1.3966 mL | 6.9828 mL | 13.9655 mL | |
| 10 mM | 0.6983 mL | 3.4914 mL | 6.9828 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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