| Size | Price | Stock | Qty |
|---|---|---|---|
| 10g |
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| 25g |
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| Other Sizes |
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Purity: ≥98%
| ln Vitro |
4-Quinolone (Kynurine) promotes tumor cell survival and motility via autocrinely/paracrinely inhibiting anti-tumor immune responses via AhR. This mechanism is especially active in human brain tumors, where kynurenine production and TDO expression are both increased by AhR activation. TDO protein levels are extremely low in healthy human brains, but they rise with the aggressiveness of human brain tumors [3].
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| References |
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| Additional Infomation |
4-quinolone is a quinolone that is 1,4-dihydroquinoline substituted by an oxo group at position 4. It is a tautomer of a quinolin-4-ol.
4-Hydroxyquinoline has been reported in Glycosmis parviflora and Glycosmis citrifolia with data available. |
| Molecular Formula |
C9H12N2O
|
|---|---|
| Molecular Weight |
164.21
|
| Exact Mass |
145.052
|
| CAS # |
611-36-9
|
| Related CAS # |
611-36-9;
|
| PubChem CID |
69141
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| Appearance |
White to light brown solid powder
|
| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
313.0±15.0 °C at 760 mmHg
|
| Melting Point |
200-202 °C(lit.)
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| Flash Point |
143.1±20.4 °C
|
| Vapour Pressure |
0.0±0.7 mmHg at 25°C
|
| Index of Refraction |
1.691
|
| LogP |
2.45
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| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
0
|
| Heavy Atom Count |
11
|
| Complexity |
198
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
PMZDQRJGMBOQBF-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C9H7NO/c11-9-5-6-10-8-4-2-1-3-7(8)9/h1-6H,(H,10,11)
|
| Chemical Name |
4-Hydroxyquinoline
|
| Synonyms |
4-Hydroxyquinoline 4 Hydroxyquinoline 4Hydroxyquinoline Kynurine
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~688.90 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (17.22 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (17.22 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (17.22 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.0898 mL | 30.4488 mL | 60.8976 mL | |
| 5 mM | 1.2180 mL | 6.0898 mL | 12.1795 mL | |
| 10 mM | 0.6090 mL | 3.0449 mL | 6.0898 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT02153541 | NOT YET RECRUITING | Drug: Antipyrine-benzocaine otic solution Other: Glycerin with Oxyquinoline Sulfate |
Asthma | Global United Pharmaceutical Corporation | 2023-04-01 | Phase 2 |
| NCT04492501 | COMPLETED | Procedure: Therapeutic Plasma exchange Biological: Convalescent Plasma Drug: Tocilizumab |
ARDS Covid19 Critical Illness Cytokine Release Syndrome |
UNICEF | 2020-04-01 | Not Applicable |
| NCT01429012 | WITHDRAWN | Biological: Mesenchymal Stem Cells Other: Culture medium without MSC. |
Nonunion Fracture | University of Liege | 2012-11 | Phase 2 |
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