| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 500mg |
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| Other Sizes |
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| ln Vitro |
4-Diethylaminobenzaldehyde (DEAB) forms a persistent covalent acetylase species, which irreversibly inactivates ALDH7A1, and is a reversible competitor (competes with the aldehyde substrate) for ALDH1 with a Ki value of 4 nM[1]. TMZ and 4-diethylaminobenzaldehyde were applied to the introduced cell line LN18 for ten days. The clonogenic potential of LN18 cells was significantly disrupted by TMZ in combination with 4-diethylaminobenzaldehyde (DEAB), according to the colony assay [3].
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| References | |
| Additional Infomation |
4-(diethylamino)benzaldehyde is a member of the class of benzaldehydes carrying a diethylamino substituent at position 4. It has a role as an EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor. It is a member of benzaldehydes, a tertiary amino compound and an aromatic amine.
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| Molecular Formula |
C₁₁H₁₅NO
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|---|---|
| Molecular Weight |
177.24
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| Exact Mass |
177.115
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| CAS # |
120-21-8
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| PubChem CID |
67114
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| Appearance |
Yellow to brown solid powder
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
329.6±0.0 °C at 760 mmHg
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| Melting Point |
37-41 °C(lit.)
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| Flash Point |
110.2±12.0 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
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| Index of Refraction |
1.571
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| LogP |
2.87
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
13
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| Complexity |
146
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
MNFZZNNFORDXSV-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11H15NO/c1-3-12(4-2)11-7-5-10(9-13)6-8-11/h5-9H,3-4H2,1-2H3
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| Chemical Name |
4-(diethylamino)benzaldehyde
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| Synonyms |
4Diethylaminobenzaldehyde; 4 Diethylaminobenzaldehyde
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~564.21 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 3.25 mg/mL (18.34 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 32.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.6421 mL | 28.2103 mL | 56.4207 mL | |
| 5 mM | 1.1284 mL | 5.6421 mL | 11.2841 mL | |
| 10 mM | 0.5642 mL | 2.8210 mL | 5.6421 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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