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| Other Sizes |
| Targets |
4-Amino-L-phenylalanine does not have a well-defined pharmacological target, as it is primarily a research chemical and metabolite. It is a TcCA activator, used in studying protozoan pathogen infections. The compound's amino and carboxyl groups, along with its para-amino phenyl ring, allow it to interact with various enzymes and receptors. However, its specific binding targets have not been fully characterized. It is not used as a therapeutic agent.
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| ln Vitro |
4-Amino-L-phenylalanine demonstrates in vitro activity as a TcCA activator, used in studying protozoan pathogen infections. It is also used in the purification of peptide synthetases involved in pristinamycin I biosynthesis. The compound's non-proteinogenic amino acid structure makes it a valuable tool for studying enzyme specificity and protein engineering. However, detailed in vitro activity data, including EC50 values, are limited.
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| ln Vivo |
In vivo activity of 4-Amino-L-phenylalanine is related to its role as an endogenous metabolite. It is metabolized by the body and excreted. The compound is not used therapeutically, and comprehensive in vivo studies evaluating its pharmacokinetic properties, efficacy, and safety are limited. Its primary applications are in research and as a building block for the synthesis of other compounds.
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| Enzyme Assay |
In vitro enzyme/receptor binding experiments for 4-Amino-L-phenylalanine may involve studying its interactions with peptide synthetases or other enzymes. The compound is used in the purification of peptide synthetases involved in pristinamycin I biosynthesis. Its chemical properties are characterized using standard analytical methods such as HPLC and mass spectrometry. The compound is also used as a reference standard in analytical chemistry.
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| Cell Assay |
In vitro cellular experiments for 4-Amino-L-phenylalanine may involve studying its effects on cells as a TcCA activator or as a precursor for other compounds. Cells are treated with the compound, and its effects on cellular processes are measured. The compound's effects on cell viability and proliferation are also assessed. Cytotoxicity assays are performed to ensure that the observed effects are not due to cell death.
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| Animal Protocol |
In vivo animal experiments for 4-Amino-L-phenylalanine are not typical, as it is a research chemical rather than a drug candidate. Studies may involve administering the compound to animals to study its metabolism or its effects on protozoan pathogen infections. However, comprehensive in vivo studies evaluating its pharmacokinetic properties are limited.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of 4-Amino-L-phenylalanine have not been extensively characterized. With a molecular weight of 180.20, the compound is expected to have moderate water solubility. It is an amino acid derivative and is likely metabolized as part of normal amino acid metabolism. Detailed studies on its absorption, distribution, metabolism, and excretion are limited. It has a melting point of 232-240°C.
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| Toxicity/Toxicokinetics |
Toxicological data for 4-Amino-L-phenylalanine are limited. As an amino acid derivative, it is expected to have low toxicity. However, comprehensive toxicology studies have not been extensively reported. Standard safety precautions for handling amino acids and their derivatives apply, including the use of personal protective equipment and working in a well-ventilated area.
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| Additional Infomation |
4-Amino-L-phenylalanine is the L-enantiomer of 4-aminophenylalanine, an enantiomer of 4-amino-D-phenylalanine, and a zwitterion tautomer of 4-amino-L-phenylalanine. It has been reported that p-aminophenylalanine has been detected in cowpea (Vigna vexillata), black cumin (Vigna angivensis), and other organisms with relevant data.
4-Amino-L-phenylalanine is a research compound that has not entered clinical trials or received regulatory approval for therapeutic use. It is primarily used as a building block in peptide synthesis and protein engineering, as a TcCA activator for studying protozoan pathogen infections, and in the production of Chloramphenicol. The compound is also an endogenous metabolite and is known as L-Phe(4-NH2)-OH. Further research is needed to explore its potential biological activities. |
| Molecular Formula |
C₉H₁₂N₂O₂
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|---|---|
| Molecular Weight |
180.20
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| Exact Mass |
180.089
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| CAS # |
943-80-6
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| PubChem CID |
151001
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| Appearance |
White to off-white solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
383.5±32.0 °C at 760 mmHg
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| Flash Point |
185.8±25.1 °C
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| Vapour Pressure |
0.0±0.9 mmHg at 25°C
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| Index of Refraction |
1.630
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| LogP |
-0.17
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
13
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| Complexity |
177
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C1=CC(=CC=C1C[C@@H](C(=O)O)N)N
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| InChi Key |
CMUHFUGDYMFHEI-QMMMGPOBSA-N
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| InChi Code |
InChI=1S/C9H12N2O2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,10-11H2,(H,12,13)/t8-/m0/s1
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| Chemical Name |
(2S)-2-amino-3-(4-aminophenyl)propanoic acid
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| Synonyms |
4AminoLphenylalanine; 4 Amino L phenylalanine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~3.33 mg/mL (~18.48 mM)
DMSO :< 1 mg/mL |
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| Solubility (In Vivo) |
Solubility in Formulation 1: 10 mg/mL (55.49 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.5494 mL | 27.7469 mL | 55.4939 mL | |
| 5 mM | 1.1099 mL | 5.5494 mL | 11.0988 mL | |
| 10 mM | 0.5549 mL | 2.7747 mL | 5.5494 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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