| Size | Price | Stock | Qty |
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| 10mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg | |||
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| Targets |
4-Allylcatechol targets multiple cellular pathways including collagen-induced platelet aggregation, with an IC₅₀ of 5.3 μM. It also exhibits activity against Mycobacterium tuberculosis H37Rv with an MIC of 27.6 μg/mL. The compound acts as an antioxidant by scavenging free radicals and singlet oxygen, protecting mitochondria from photosensitization-induced damage. It has been reported as an antimicrobial, antioxidant, and anti-inflammatory agent with diverse pharmacological activities.
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| ln Vitro |
In vitro, 4-allylcatechol shows strong inhibitory activity against collagen-induced platelet aggregation with an IC₅₀ of 5.3 μM. It exhibits antitubercular activity against Mycobacterium tuberculosis H37Rv with an MIC of 27.6 μg/mL. The compound demonstrates potent antioxidant activity, protecting rat liver mitochondria from photosensitization-induced damage to lipids and proteins by scavenging free radicals and singlet oxygen. It also shows cytotoxicity in HT29 cells and anti-inflammatory activity.
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| ln Vivo |
In vivo, 4-allylcatechol has been shown to reduce cognitive deficits and mitigate oxidative stress in animal models, suggesting neuroprotective effects in Alzheimer's disease models. Its antioxidant properties protect against oxidative damage in various tissues. The compound's anti-inflammatory activity has been demonstrated in animal models of inflammation. The compound is naturally consumed as part of betel leaf chewing, suggesting low toxicity in traditional use.
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| Enzyme Assay |
For non-cell enzyme/receptor binding assays, 4-allylcatechol antioxidant activity is assessed using cell-free radical-scavenging assays such as DPPH, ABTS, and ORAC. The compound's ability to scavenge free radicals and singlet oxygen is measured spectrophotometrically. Its protective effects on lipids and proteins can be assessed using mitochondrial membrane preparations exposed to photosensitization-induced damage. IC₅₀ values for various activities are determined from dose-response curves.
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| Cell Assay |
For in vitro cell-based assays, 4-allylcatechol is tested in various cell types including platelets, cancer cells, and neuronal cells. Platelet aggregation assays measure the compound's inhibitory effect on collagen-induced aggregation. Cytotoxicity is assessed in HT29 cells using cell viability assays. Antioxidant activity is measured by assessing protection against oxidative stress-induced cell damage. Neuroprotective effects are evaluated in neuronal cell models of Alzheimer's disease.
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| Animal Protocol |
For in vivo animal experiments, 4-allylcatechol is typically administered orally or intraperitoneally to rodent models. Cognitive function is assessed in Alzheimer's disease models using behavioral tests. Oxidative stress markers are measured in brain and other tissues. The compound's anti-inflammatory activity is evaluated in inflammation models. Mitochondrial function and oxidative damage are assessed in liver and other tissues following compound administration.
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| ADME/Pharmacokinetics |
Metabolism / Metabolites
Hydroxychavone is a known metabolite of eugenol in the human body. 4-Allylcatechol has a molecular weight of 150.17 g/mol and molecular formula C₉H₁₀O₂. It appears as a solid and is soluble in organic solvents. The compound should be stored at 2-8°C for stability. It is a natural phenylpropanoid with purity ≥98% available for research purposes. The compound is an intermediate in safrole synthesis and is found naturally in Piper betle leaves. |
| Toxicity/Toxicokinetics |
4-Allylcatechol is considered a natural compound with low toxicity based on its traditional use in betel leaf consumption. It has been consumed by people for many centuries and is obviously non-toxic at normal dietary levels. The compound is for research use only and is not approved as a pharmaceutical drug. Standard safety precautions for handling natural products should be followed.
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| Additional Infomation |
4-Allylcatechol has been reported in Cambodian dragon's blood tree (Dracaena cambodiana), turmeric (Alpinia officinarum), and other organisms with available data. See also: safrole (note moved to).
4-Allylcatechol (hydroxychavicol) is a naturally occurring phenylpropanoid found in Piper betle leaves, which have been chewed for centuries in traditional practices. The compound exhibits diverse pharmacological activities including antimicrobial, antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. It has been studied for its potential in treating infections, cancer, immune-inflammatory conditions, and neurological diseases. No clinical trials have been conducted for this compound as a therapeutic agent. It is available for research purposes only. |
| Molecular Formula |
C9H10O2
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|---|---|
| Molecular Weight |
150.1745
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| Exact Mass |
150.068
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| CAS # |
1126-61-0
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| PubChem CID |
70775
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| Appearance |
Off-white to brown solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
289.2±25.0 °C at 760 mmHg
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| Melting Point |
42.0 to 46.0 °C
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| Flash Point |
141.7±17.8 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
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| Index of Refraction |
1.587
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| LogP |
1.9
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
11
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| Complexity |
134
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
FHEHIXJLCWUPCZ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C9H10O2/c1-2-3-7-4-5-8(10)9(11)6-7/h2,4-6,10-11H,1,3H2
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| Chemical Name |
4-prop-2-enylbenzene-1,2-diol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~665.91 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.65 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.65 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (16.65 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.6591 mL | 33.2956 mL | 66.5912 mL | |
| 5 mM | 1.3318 mL | 6.6591 mL | 13.3182 mL | |
| 10 mM | 0.6659 mL | 3.3296 mL | 6.6591 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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