| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
|
||
| 100mg |
|
||
| 250mg |
|
||
| 500mg |
|
||
| Other Sizes |
| Targets |
4,4'-Dimethoxychalcone regulates redox homeostasis by targeting riboflavin metabolism in Parkinson's disease therapy. It acts as a natural autophagy inducer with anti-ageing properties and has cardioprotective effects.
|
|---|---|
| ln Vitro |
4,4'-Dimethoxychalcone exhibits in vitro anti-inflammatory and antioxidant effects. It acts as a natural autophagy inducer and has been studied for its potential therapeutic applications.
|
| ln Vivo |
The anti-aging flavonoid 4,4'-dimethoxychalcone protects the mouse heart and may lengthen life spans in all species [1]. Intraperitoneal dose: 100 mg/kg of 4,4'-Dimethoxychalcone
The flavonoid 4,4'-Dimethoxychalcone acts as an anti-ageing compound with cardioprotective effects in mice and the potential to promote longevity across species. In vivo, it has shown anti-ageing properties. |
| Enzyme Assay |
Autophagy induction assays are performed using cell lines treated with 4,4'-Dimethoxychalcone. Autophagy markers such as LC3-II are measured by Western blot. Antioxidant activity is assessed using DPPH or other radical scavenging assays.
|
| Cell Assay |
Cell-based assays are conducted to evaluate autophagy induction, anti-inflammatory effects, and antioxidant activity. The compound's effects on cellular pathways are assessed in appropriate cell models.
|
| Animal Protocol |
Animal/Disease Models: 6weeks old male wild-type C57BL/6 or Atg4b-/- mice [1]
Doses: 100 mg/kg Route of Administration: One intraperitoneal (ip) injection Experimental Results: Triggers autophagic flow in heart and liver. In vivo studies are performed in mouse models to assess cardioprotective effects and anti-ageing properties. The compound's potential to promote longevity is evaluated across species. |
| ADME/Pharmacokinetics |
4,4'-Dimethoxychalcone has a molecular formula of C17H16O3. Storage: standard conditions for research compounds. The compound is soluble in organic solvents.
|
| Toxicity/Toxicokinetics |
4,4'-Dimethoxychalcone is not classified as a hazardous compound under normal handling conditions. Standard laboratory safety precautions should be followed when handling the compound.
|
| References | |
| Additional Infomation |
See also: Angelica sinensis (partial).
4,4'-Dimethoxychalcone is a naturally occurring chalcone with anti-ageing and cardioprotective properties. It acts as a natural autophagy inducer and regulates redox homeostasis. Synonyms include 4,4'-甲氧基查耳酮. |
| Molecular Formula |
C₁₇H₁₆O₃
|
|---|---|
| Molecular Weight |
268.31
|
| Exact Mass |
268.11
|
| CAS # |
2373-89-9
|
| PubChem CID |
5377817
|
| Appearance |
Light yellow to yellow solid powder
|
| Density |
1.128g/cm3
|
| Boiling Point |
444.6ºC at 760 mmHg
|
| Melting Point |
101°C
|
| Flash Point |
214.6ºC
|
| Vapour Pressure |
4.23E-08mmHg at 25°C
|
| Index of Refraction |
1.591
|
| LogP |
3.599
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
5
|
| Heavy Atom Count |
20
|
| Complexity |
321
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
COC1=CC=C(C=C1)/C=C/C(=O)C2=CC=C(C=C2)OC
|
| InChi Key |
HDXVSZWKIHQDES-LFYBBSHMSA-N
|
| InChi Code |
InChI=1S/C17H16O3/c1-19-15-8-3-13(4-9-15)5-12-17(18)14-6-10-16(20-2)11-7-14/h3-12H,1-2H3/b12-5+
|
| Chemical Name |
(E)-1,3-bis(4-methoxyphenyl)prop-2-en-1-one
|
| Synonyms |
4,4'Dimethoxychalcone; 4,4' Dimethoxychalcone
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 250 mg/mL (~931.76 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 6.25 mg/mL (23.29 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 6.25 mg/mL (23.29 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 900 μL corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7270 mL | 18.6352 mL | 37.2703 mL | |
| 5 mM | 0.7454 mL | 3.7270 mL | 7.4541 mL | |
| 10 mM | 0.3727 mL | 1.8635 mL | 3.7270 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
