| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
3,4-Methylenedioxycinnamic acid targets Human Flap endonuclease 1 (FEN1), an enzyme involved in DNA replication and repair. It also targets the phenylpropanoid enzyme 4-hydroxycinnamoyl-CoA ligase. Its inhibition of FEN1 suggests potential applications in cancer research, as FEN1 is a target for anticancer therapy. Its antiviral activity against Influenza A virus indicates it may interact with viral components, though specific mechanisms are not detailed.
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|---|---|
| ln Vitro |
In vitro, 3,4-Methylenedioxycinnamic acid is a potent inhibitor of FEN1 with a potency of 31622.8 nM. It also exhibits antiviral activity against Influenza A virus (H1N1), with EC₅₀ and IC₅₀ values greater than 100,000 nM. The compound has potential antioxidant, anti-inflammatory, and antimicrobial properties. Specific cellular assay data, such as effects on cell viability or viral replication, are not detailed.
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| ln Vivo |
Specific in vivo activity data for 3,4-Methylenedioxycinnamic acid are not provided in the available sources. The compound's potential therapeutic applications in treating conditions like cancer, inflammation, and neurodegenerative diseases have been suggested, but no in vivo studies are described.
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| Enzyme Assay |
A cell-free assay for 3,4-Methylenedioxycinnamic acid would involve measuring its inhibition of FEN1 enzymatic activity. In such assays, the enzyme is incubated with a DNA substrate and the compound, and the rate of DNA cleavage is measured. The compound's potency is 31622.8 nM. Its antiviral activity could be assessed in cell-based assays rather than cell-free systems.
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| Cell Assay |
Cellular assays for 3,4-Methylenedioxycinnamic acid would typically involve evaluating its effects on cancer cell lines or virus-infected cells. For FEN1 inhibition, effects on DNA repair and cell proliferation could be assessed. For antiviral activity, inhibition of viral replication in infected cells could be measured. Specific protocols are not detailed in the available sources.
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| Animal Protocol |
In vivo animal experiments for 3,4-Methylenedioxycinnamic acid are not described in the available sources. As a compound with potential anticancer and antiviral activities, it could be evaluated in appropriate animal models, but no specific data or protocols are provided.
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| ADME/Pharmacokinetics |
Pharmacokinetic (PK) properties of 3,4-Methylenedioxycinnamic acid are not reported in the available sources. As a small molecule, its absorption, distribution, metabolism, and excretion (ADME) profiles have not been characterized. The compound is soluble in DMSO. Standard storage conditions for research compounds apply.
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| Toxicity/Toxicokinetics |
Toxicity data for 3,4-Methylenedioxycinnamic acid are not provided in the available sources. As with all research compounds, it is intended for research use only and not for human consumption. Standard laboratory safety precautions should be observed when handling this compound.
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| References | |
| Additional Infomation |
Methylenedioxycinnamic acid is a type of hydroxycinnamic acid. It has been reported to be found in both Brombya platynema and Helichrysum arenarium, and relevant data are available for reference.
3,4-Methylenedioxycinnamic acid (CAS: 38489-76-8) is a cinnamic acid derivative also known as MDCA. It is a potent inhibitor of Human Flap endonuclease 1 (FEN1) with a potency of 31622.8 nM. It also shows antiviral activity against Influenza A virus (H1N1). The compound has been studied for its potential antioxidant, anti-inflammatory, and antimicrobial properties. It is not an approved drug and is primarily used as a research chemical. Its molecular formula is C₁₀H₈O₄ with a molecular weight of 192.17. |
| Molecular Formula |
C10H8O4
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|---|---|
| Molecular Weight |
192.17
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| Exact Mass |
192.042
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| CAS # |
38489-76-8
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| PubChem CID |
643181
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| Appearance |
White to off-white solid powder
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| Density |
1.41
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| Boiling Point |
361.5ºC at 760 mmHg
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| Flash Point |
148.9ºC
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| LogP |
1.513
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
14
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| Complexity |
249
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1OC2=C(O1)C=C(C=C2)/C=C/C(=O)O
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| InChi Key |
QFQYZMGOKIROEC-DUXPYHPUSA-N
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| InChi Code |
InChI=1S/C10H8O4/c11-10(12)4-2-7-1-3-8-9(5-7)14-6-13-8/h1-5H,6H2,(H,11,12)/b4-2+
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| Chemical Name |
(E)-3-(1,3-benzodioxol-5-yl)prop-2-enoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~260.19 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1 mg/mL (5.20 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.2037 mL | 26.0186 mL | 52.0373 mL | |
| 5 mM | 1.0407 mL | 5.2037 mL | 10.4075 mL | |
| 10 mM | 0.5204 mL | 2.6019 mL | 5.2037 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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