| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 100mg | |||
| Other Sizes |
| Targets |
3-O-Methylgalangin targets pancreatic lipase, inhibiting its activity. It also exhibits antibacterial and antifungal effects, likely by disrupting microbial cell membranes or inhibiting essential microbial enzymes. Its antioxidant activity is attributed to its ability to scavenge free radicals.
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| ln Vitro |
In vitro, 3-O-Methylgalangin demonstrates significant antibacterial and antifungal activities. It inhibits pancreatic lipase, suggesting potential for studying lipid metabolism. It also exhibits potent antioxidant and anti-inflammatory properties.
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| ln Vivo |
In vivo, the antibacterial and anti-inflammatory activities of 3-O-Methylgalangin suggest potential therapeutic applications. However, specific in vivo data are limited. Its ability to inhibit pancreatic lipase could be relevant for studies on obesity and fat absorption.
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| Enzyme Assay |
In vitro non-cell enzyme assays for 3-O-Methylgalangin typically involve measuring the inhibition of pancreatic lipase activity using a chromogenic substrate (e.g., p-nitrophenyl palmitate). The compound is incubated with the enzyme and substrate, and the release of the chromophore is measured spectrophotometrically. IC₅₀ values are calculated.
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| Cell Assay |
In vitro cell-based assays for 3-O-Methylgalangin use bacterial and fungal cultures to determine its minimum inhibitory concentrations (MICs) using broth microdilution or agar diffusion methods. For anti-inflammatory studies, macrophages can be treated with the compound and stimulated with LPS, and the production of inflammatory cytokines (e.g., TNF-α, IL-6) is measured by ELISA.
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| Animal Protocol |
In vivo animal studies for 3-O-Methylgalangin are limited. Standard protocols for studying antibacterial activity would involve infecting animal models (e.g., mice) with a pathogen and then treating them with the compound to assess survival and bacterial load. Its anti-inflammatory effects could be studied in models of acute inflammation.
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| ADME/Pharmacokinetics |
3-O-Methylgalangin has a molecular weight of 284.26 g/mol and a molecular formula of C₁₆H₁₂O₅. It is a flavonoid compound with a purity of >98.0% by HPLC. It is soluble in organic solvents. Detailed pharmacokinetic parameters have not been extensively characterized.
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| Toxicity/Toxicokinetics |
The toxicity profile of 3-O-Methylgalangin has not been fully characterized. As a natural compound from a commonly used spice, it is generally considered to have low toxicity. However, comprehensive toxicological studies are needed to confirm its safety for therapeutic use.
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| References |
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| Additional Infomation |
3-Methylgalangin is a monomethoxyflavonoid, a compound in which the 3-hydroxyl group of galangin is replaced by a methoxy group. It is a plant metabolite. It is both a dihydroxyflavonoid and a monomethoxyflavonoid. Its function is related to that of galangin. Galangin 3-methyl ether has been reported to exist in turmeric (Alpinia officinarum), poplar (Populus nigra), and other organisms with relevant data.
3-O-Methylgalangin is a naturally occurring flavonoid from galangal with significant antibacterial, antifungal, and anti-lipase activities. It is also known as Galangin 3-methyl ether and 5,7-Dihydroxy-3-methoxyflavone. It is a valuable research tool for studying infectious diseases, lipid metabolism, and inflammation. Not approved for clinical use. |
| Molecular Formula |
C16H12O5
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|---|---|
| Molecular Weight |
284.2635
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| Exact Mass |
284.068
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| CAS # |
6665-74-3
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| PubChem CID |
5281946
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| Appearance |
Light yellow to yellow solid powder
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| Density |
1.47g/cm3
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| Boiling Point |
526.4ºC at 760 mmHg
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| Melting Point |
299 ºC
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| Flash Point |
201.5ºC
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| Index of Refraction |
1.692
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| LogP |
2.879
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
21
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| Complexity |
438
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
LYISDADPVOHJBJ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H12O5/c1-20-16-14(19)13-11(18)7-10(17)8-12(13)21-15(16)9-5-3-2-4-6-9/h2-8,17-18H,1H3
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| Chemical Name |
5,7-dihydroxy-3-methoxy-2-phenylchromen-4-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~12.5 mg/mL (~43.97 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.25 mg/mL (4.40 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5179 mL | 17.5895 mL | 35.1791 mL | |
| 5 mM | 0.7036 mL | 3.5179 mL | 7.0358 mL | |
| 10 mM | 0.3518 mL | 1.7590 mL | 3.5179 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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