| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
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| ln Vitro |
Methionine has often been demonstrated to be the most hazardous amino acid in tests intended to evaluate the relative toxicity of dietary amino acids. 3. In vitro methionine catabolism in the livers of rats and monkeys produces methylthiopropionic acid as an intermediary. It seems that a significant amount of methionine oxidation occurs in vitro through this mechanism [1]. The total quantity of 3-methylthioacrylic acid that S. Methionine content in the culture medium has a direct impact on Lincolnsis cultures. This route may start with a ketoacid as the first step, which is subsequently converted to 3-methylthiopropionic acid through oxidative decarboxylation [2]. employing Fusarium oxysporum as a model fungus, experiments employing purified 3-MTPA demonstrated antifungal efficacy. Partially purified extracts at doses more than 12 mg significantly decreased seed germination and root and shoot development, as demonstrated by daily measurements of shoot and root length [3]. By stimulating differentiation in colon cancer cells that have undergone complete differentiation, ethyl 3-methylthiopropionate has possible anticancer effects. In addition to causing an increase in the number and maximum diameter of catheters per culture plate, treatment of RCM-1 cells with ethyl 3-methylthiopropionate at doses of 0.25 to 2 mM for 4 days gradually increased the percentage of area occupied by conduit structures relative to the control.
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| References |
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| Additional Infomation |
3-(methylthio)propionic acid is a thia fatty acid acid consisting of propionic acid with a methylthio substituent at the 3-position; an intermediate in mammalian methionine metabolism in vitro. The simplest known phytotoxin, it is a blight-inducing toxin produced by the cassava pathogen Xanthomonas campestris manihotis. It has a role as a phytotoxin. It is functionally related to a propionic acid. It is a conjugate acid of a 3-(methylthio)propionate.
3-Methylsulfoniopropionate has been reported in Homo sapiens, Streptomyces celluloflavus, and other organisms with data available. |
| Molecular Formula |
C4H8O2S
|
|---|---|
| Molecular Weight |
120.1701
|
| Exact Mass |
120.024
|
| CAS # |
646-01-5
|
| PubChem CID |
563
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| Appearance |
Colorless to light yellow liquid
|
| Density |
1.16
|
| Boiling Point |
130ºC 2mm
|
| Melting Point |
16ºC
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| Flash Point |
130°C/15mm
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| Index of Refraction |
1.4884
|
| LogP |
1.671
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
7
|
| Complexity |
62.7
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
S(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)O[H]
|
| InChi Key |
CAOMCZAIALVUPA-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C4H8O2S/c1-7-3-2-4(5)6/h2-3H2,1H3,(H,5,6)
|
| Chemical Name |
3-methylsulfanylpropanoic acid
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~25 mg/mL (~208.04 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (832.15 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.3215 mL | 41.6077 mL | 83.2154 mL | |
| 5 mM | 1.6643 mL | 8.3215 mL | 16.6431 mL | |
| 10 mM | 0.8322 mL | 4.1608 mL | 8.3215 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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