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| Other Sizes |
| Targets |
3-Methoxyflavone does not have a well-defined specific pharmacological target in mammalian systems. As a flavonoid compound, it may interact with various cellular pathways involved in antiviral defense. Flavonoids are known to modulate enzyme activities, including kinases and oxidoreductases, and may exert their effects through antioxidant and anti-inflammatory mechanisms.
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| ln Vitro |
In vitro, 3-Methoxyflavone has demonstrated antiviral activity. The compound is a natural flavonoid extracted from Artemisia incanescens. Detailed in vitro activity data, including specific antiviral assays, IC50 values, and cell lines tested, are limited in the available literature. As a flavonoid, it may also exhibit antioxidant and anti-inflammatory properties.
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| ln Vivo |
In vivo data for 3-Methoxyflavone are limited in the available literature. The compound is a natural product that has been studied primarily for its in vitro antiviral properties. Further in vivo studies are needed to evaluate its therapeutic potential and pharmacokinetic properties.
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| Enzyme Assay |
3-Methoxyflavone's mechanism of action has not been extensively characterized in the available literature. As a flavonoid, it may exert antiviral effects through inhibition of viral enzymes, disruption of viral entry, or modulation of host immune responses. Detailed receptor-binding or enzyme inhibition studies have not been reported.
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| Cell Assay |
In vitro antiviral assays using 3-Methoxyflavone typically involve testing the compound against various viruses using standard cytopathic effect (CPE) inhibition or plaque reduction assays. The compound's antiviral activity is assessed by measuring the reduction in viral replication or viral-induced cell death. Concentrations and incubation times vary depending on the specific virus and experimental design.
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| Animal Protocol |
In vivo animal studies using 3-Methoxyflavone have not been reported in the available literature. The compound is primarily studied for its in vitro antiviral properties. Further studies are needed to evaluate its in vivo efficacy and safety.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 3-Methoxyflavone are not available in the searched literature. As a flavonoid compound with a molecular weight of 252.26 g/mol and an XLogP3 of 3.7, it is expected to have moderate lipophilicity and may be absorbed after oral administration. Further pharmacokinetic studies are needed.
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| Toxicity/Toxicokinetics |
Toxicological data for 3-Methoxyflavone are limited. As a flavonoid compound, it is generally considered to have a favorable safety profile. The compound appears as a white to off-white powder to crystal with a melting point of 112.0 to 116.0 °C and purity of ≥98%.
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| References | |
| Additional Infomation |
3-Methoxyflavone (CAS 7245-02-5) is a synthetic O-methylated flavonoid belonging to the flavone class. It has a molecular formula of C16H12O3 and a molecular weight of 252.26 g/mol. The compound is stored at room temperature or as a powder at 2-8°C for up to 2 years. It is primarily used in antiviral research.
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| Molecular Formula |
C16H12O3
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|---|---|
| Molecular Weight |
252.2647
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| Exact Mass |
252.078
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| CAS # |
7245-02-5
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| PubChem CID |
146013
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| Appearance |
Off-white to light yellow solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
408.4±45.0 °C at 760 mmHg
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| Melting Point |
114-115ºC (dec.)(lit.)
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| Flash Point |
192.4±15.1 °C
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| Vapour Pressure |
0.0±1.0 mmHg at 25°C
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| Index of Refraction |
1.631
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| LogP |
2.84
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
19
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| Complexity |
380
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
ZAIANDVQAMEDFL-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H12O3/c1-18-16-14(17)12-9-5-6-10-13(12)19-15(16)11-7-3-2-4-8-11/h2-10H,1H3
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| Chemical Name |
3-methoxy-2-phenylchromen-4-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~396.42 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.91 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.91 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (9.91 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9642 mL | 19.8208 mL | 39.6416 mL | |
| 5 mM | 0.7928 mL | 3.9642 mL | 7.9283 mL | |
| 10 mM | 0.3964 mL | 1.9821 mL | 3.9642 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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