| Size | Price | Stock | Qty |
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| 25g |
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| 50g |
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| Other Sizes |
| Targets |
3-Hydroxybenzaldehyde is a substrate for aldehyde dehydrogenase (ALDH), particularly ALDH2 in humans. It exhibits inhibitory effects on Pieris rapae Phenoloxidase with IC50 values of 9.62 μM and 104.71 nM. The compound has vasculoprotective effects.
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| ln Vitro |
3-Hydroxybenzaldehyde (0-100 μM, 24 h) inhibits vascular smooth muscle cell (VSMC) proliferation, cell cycle, and cell migration. It has vasculoprotective effects in vitro. The compound inhibits phenoloxidase with IC50 values of 9.62 μM and 104.71 nM.
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| ln Vivo |
3-Hydroxybenzaldehyde has vasculoprotective effects in vivo. It is promising for research of atherosclerosis. The compound is a substrate of ALDH, suggesting it may be metabolized in vivo.
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| Enzyme Assay |
ALDH activity assays are performed using recombinant ALDH enzyme. 3-Hydroxybenzaldehyde is incubated with the enzyme and substrate, and ALDH activity is measured. Phenoloxidase inhibition assays are conducted to determine IC50 values.
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| Cell Assay |
Cell-based assays are conducted using vascular smooth muscle cells (VSMC). Cells are treated with 3-Hydroxybenzaldehyde (0-100 μM, 24 h), and proliferation, cell cycle, and migration are assessed. The compound's vasculoprotective effects are evaluated in endothelial cells.
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| Animal Protocol |
In vivo studies are performed in animal models of atherosclerosis. The compound's vasculoprotective effects are assessed. Specific dosing and administration details are not extensively reported in the available literature.
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| ADME/Pharmacokinetics |
3-Hydroxybenzaldehyde has a molecular weight of 122.12 and a molecular formula of C7H6O2. Storage: standard conditions for research compounds. The compound is soluble in organic solvents.
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| Toxicity/Toxicokinetics |
3-Hydroxybenzaldehyde is not classified as a hazardous compound under normal handling conditions. Standard laboratory safety precautions should be followed when handling the compound.
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| References | |
| Additional Infomation |
3-Hydroxybenzaldehyde is a hydroxybenzaldehyde with a hydroxyl substituent at the 3-position. It has been reported in Penicillium, Ziziphus jujuba, and other organisms for which data is available.
3-Hydroxybenzaldehyde is a substrate of ALDH with vasculoprotective effects. It is a precursor for phenolic compounds and is promising for research of atherosclerosis. Synonyms include 3-HBA and m-Hydroxybenzaldehyde. |
| Molecular Formula |
C₇H₆O₂
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|---|---|
| Molecular Weight |
122.12
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| Exact Mass |
122.036
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| CAS # |
100-83-4
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| PubChem CID |
101
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| Appearance |
Off-white to light yellow solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
240.9±13.0 °C at 760 mmHg
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| Melting Point |
100-103 °C(lit.)
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| Flash Point |
98.6±12.4 °C
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| Vapour Pressure |
0.0±0.5 mmHg at 25°C
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| Index of Refraction |
1.618
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| LogP |
1.25
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
9
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| Complexity |
101
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
IAVREABSGIHHMO-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C7H6O2/c8-5-6-2-1-3-7(9)4-6/h1-5,9H
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| Chemical Name |
3-hydroxybenzaldehyde
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| Synonyms |
3Hydroxybenzaldehyde; 3 Hydroxybenzaldehyde
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~818.87 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (20.47 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (20.47 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (20.47 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.1887 mL | 40.9433 mL | 81.8867 mL | |
| 5 mM | 1.6377 mL | 8.1887 mL | 16.3773 mL | |
| 10 mM | 0.8189 mL | 4.0943 mL | 8.1887 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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