| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
|
||
| Other Sizes |
| References | |
|---|---|
| Additional Infomation |
3-Chloro-L-tyrosine is a chlorinated amino acid with a chlorine substituent attached to the ortho position of the phenolic hydroxyl group in its tyrosine core structure. It is both a biomarker and a human metabolite. It is a chlorinated amino acid belonging to the monochlorobenzene class of compounds, a derivative of L-tyrosine, and also a non-protein-derived L-α-amino acid. It is a zwitterion tautomer of 3-chloro-L-tyrosine. There are reports and data regarding the presence of 3-chloro-L-tyrosine in humans. 3-Chloro-tyrosine is a specific biomarker for hypochlorous acid (HClO), an oxidation product of myeloperoxidase (MPO). Under oxidative stress, the strong oxidant hypochlorous acid generates 3-chloro-tyrosine in proteins containing tyrosine residues. Hypochlorous acid (HClO) is generated at sites of inflammation and is also an antimicrobial molecule produced by neutrophils through myeloperoxidase (MPO) catalysis. MPO is a heme-containing enzyme secreted by activated neutrophils and monocytes; it is the only enzyme capable of producing HClO. Therefore, 3-chlorotyrosine may be helpful in assessing the degree of neutrophil inflammation.
|
| Molecular Formula |
C9H10CLNO3
|
|---|---|
| Molecular Weight |
215.6336
|
| Exact Mass |
215.034
|
| CAS # |
7423-93-0
|
| Related CAS # |
3-Chloro-L-tyrosine-13C6
|
| PubChem CID |
110992
|
| Appearance |
White to off-white solid powder
|
| Density |
1.5±0.1 g/cm3
|
| Boiling Point |
388.6±42.0 °C at 760 mmHg
|
| Melting Point |
249ºC
|
| Flash Point |
188.8±27.9 °C
|
| Vapour Pressure |
0.0±0.9 mmHg at 25°C
|
| Index of Refraction |
1.625
|
| LogP |
0.93
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
14
|
| Complexity |
212
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
C1=CC(=C(C=C1C[C@@H](C(=O)O)N)Cl)O
|
| InChi Key |
ACWBBAGYTKWBCD-ZETCQYMHSA-N
|
| InChi Code |
InChI=1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
|
| Chemical Name |
(2S)-2-amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~5 mg/mL (~23.19 mM)
DMSO :< 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 6.25 mg/mL (28.98 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.6376 mL | 23.1879 mL | 46.3757 mL | |
| 5 mM | 0.9275 mL | 4.6376 mL | 9.2751 mL | |
| 10 mM | 0.4638 mL | 2.3188 mL | 4.6376 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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