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| Targets |
3-Amino-2-piperidinone does not have a specific well-defined pharmacological target, as it is primarily used as a research reagent and metabolite. As a cyclic ornithine analogue, it may interact with enzymes involved in amino acid metabolism, such as ornithine decarboxylase or arginase. Its role as a metabolite from all living organisms suggests it may be involved in various physiological processes. However, it is not typically considered a drug target compound.
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| ln Vitro |
3-Amino-2-piperidinone exhibits in vitro activity as a metabolite and cyclic ornithine analogue. It is used as a research reagent to study amino acid metabolism and enzyme function. Its activity is assessed in biochemical assays measuring enzyme activity or metabolic flux. These in vitro activities confirm its utility as a research tool in metabolism research.
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| ln Vivo |
3-Amino-2-piperidinone is not typically used as a therapeutic agent in vivo. However, as a metabolite from all living organisms, it may be involved in various physiological processes. In toxicological studies, it may be evaluated for its effects on metabolism and excretion. Its metabolic fate in vivo involves conversion to other metabolites.
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| Enzyme Assay |
3-Amino-2-piperidinone does not have specific enzyme/receptor binding assays associated with it, as it is not a typical drug target compound. However, its role as a cyclic ornithine analogue can be studied using enzyme assays for ornithine decarboxylase or arginase. Its effects on metabolic pathways can be studied using cell culture models or metabolomics techniques.
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| Cell Assay |
3-Amino-2-piperidinone is not typically used in cellular assays as a pharmacological agent. However, its effects on metabolism can be studied in cell culture models. Cytotoxicity assays can be performed to assess the compound's effects on cell viability. Metabolic flux analysis can be used to study its effects on cellular metabolism. These assays are primarily used in metabolomics and biochemical research.
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| Animal Protocol |
In vivo animal experiments with 3-Amino-2-piperidinone are primarily conducted for metabolic and toxicological studies. Rodent models are used to assess its metabolism, distribution, and excretion. The compound may be administered orally or by injection, and its levels in plasma, urine, and tissues are measured. These studies help define the compound's metabolic fate and safety profile.
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| ADME/Pharmacokinetics |
3-Amino-2-piperidinone is a small, polar molecule with a molecular weight of 114.15. It is soluble in water and organic solvents. Its pharmacokinetic profile is typical for small polar molecules. The compound is typically stored at -20°C.
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| Toxicity/Toxicokinetics |
3-Amino-2-piperidinone is considered to have low toxicity based on its use as a research compound and its occurrence as a natural metabolite. However, comprehensive toxicological evaluations have not been extensively published. The compound is intended for research use only and is not approved for human therapeutic use. Standard laboratory safety precautions should be followed when handling this compound.
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| Additional Infomation |
3-Aminopiperidin-2-one is a δ-lactam, formed by replacing the amino group at the 3-position of 2-piperidinone. It is a human metabolite. It belongs to the piperidinone class of compounds, is a primary amino compound, and is also a δ-lactam. 3-Aminopiperidinone is a metabolite found or produced in Escherichia coli (strains K12 and MG1655). It has been reported that 3-aminopiperidin-2-one exists in Neurospora alfalfa, Arabidopsis thaliana, and Vitis vinifera, and relevant data are available for reference.
3-Amino-2-piperidinone is a delta-lactam and a metabolite from all living organisms. It is also known as cyclo-ornithine. The compound is 2-piperidone substituted at position 3 by an amino group. It can be used as a cyclic ornithine analogue. It is available in high purity for research applications. Its role as a metabolite and cyclic ornithine analogue makes it a valuable tool for studying amino acid metabolism. |
| Molecular Formula |
C₅H₁₀N₂O
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|---|---|
| Molecular Weight |
114.15
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| Exact Mass |
114.079
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| CAS # |
1892-22-4
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| PubChem CID |
5200225
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| Appearance |
Yellow to brown solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
307.5±35.0 °C at 760 mmHg
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| Flash Point |
139.8±25.9 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
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| Index of Refraction |
1.477
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| LogP |
-2.2
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
8
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| Complexity |
103
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
YCCMTCQQDULIFE-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C5H10N2O/c6-4-2-1-3-7-5(4)8/h4H,1-3,6H2,(H,7,8)
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| Chemical Name |
3-aminopiperidin-2-one
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| Synonyms |
3Amino2piperidinone 3 Amino 2 piperidinone
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~438.02 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (21.90 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (21.90 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.7604 mL | 43.8020 mL | 87.6040 mL | |
| 5 mM | 1.7521 mL | 8.7604 mL | 17.5208 mL | |
| 10 mM | 0.8760 mL | 4.3802 mL | 8.7604 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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