| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
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| ln Vivo |
Following treatment with 3-amino-2-methylpropionic acid (BAIBA), the mice's body weight decreased somewhat. MRI-based body composition study revealed that BAIBA therapy dramatically decreased mice's body fat. Metabolic cage study revealed that oxygen consumption (VO2) and whole-body energy expenditure were raised in BAIBA-treated mice without any significant variations in activity or food intake, which is consistent with the effects on thermogenic and beta-oxidation gene expression and body weight. Additionally, mice were given an intraperitoneal glucose tolerance test (IPGTT) challenge. The area under the IPGTT curve indicates that BAIBA can dramatically increase mice's glucose tolerance [1].
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| References |
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| Additional Infomation |
3-aminoisobutyric acid is a beta-amino-acid that is isobutyric acid in which one of the methyl hydrogens is substituted by an amino group. It has a role as a metabolite. It is functionally related to an isobutyric acid. It is a conjugate acid of a 3-aminoisobutyrate. It is a tautomer of a 3-aminoisobutanoic acid zwitterion.
3-Azaniumyl-2-methylpropanoate has been reported in Drosophila melanogaster, Salmonella enterica, and Caenorhabditis elegans with data available. 3-Aminoisobutyric Acid is a derivative of the amino acid alanine that is a product of thymine metabolism, which has the potential to induce downstream metabolic activity. During exercise, 3-aminoisobutyric acid is secreted by muscle cells into the blood. Once this molecule interacts with adipocytes, it may induce signaling pathways that regulate the metabolism of fats, insulin, and cholesterol. |
| Molecular Formula |
C4H9NO2
|
|---|---|
| Molecular Weight |
103.1198
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| Exact Mass |
103.063
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| CAS # |
144-90-1
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| Related CAS # |
(S)-b-aminoisobutyric acid;4249-19-8;3-Amino-2-methylpropanoic acid-d3;1219803-65-2
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| PubChem CID |
64956
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| Appearance |
White to off-white solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
223.6±23.0 °C at 760 mmHg
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| Melting Point |
246.72°C (estimate)
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| Flash Point |
89.0±22.6 °C
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| Vapour Pressure |
0.0±0.9 mmHg at 25°C
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| Index of Refraction |
1.462
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| LogP |
-0.51
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
7
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| Complexity |
72.1
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
QCHPKSFMDHPSNR-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)
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| Chemical Name |
3-amino-2-methylpropanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~969.74 mM)
DMSO : ~1 mg/mL (~9.70 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (969.74 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.6974 mL | 48.4872 mL | 96.9744 mL | |
| 5 mM | 1.9395 mL | 9.6974 mL | 19.3949 mL | |
| 10 mM | 0.9697 mL | 4.8487 mL | 9.6974 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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