| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
| Targets |
3-(4-Hydroxyphenyl)-1-propanol does not have a specific therapeutic target but is used as a building block in organic synthesis. It is a reagent in the synthesis of leukotriene biosynthesis inhibitors. The compound may also have biological activities related to its phenolic structure, including antioxidant properties. In plants, it regulates growth and development.
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|---|---|
| ln Vitro |
In vitro, 3-(4-Hydroxyphenyl)-1-propanol is used as a chemical intermediate in the synthesis of bioactive compounds. It has a certain degree of regulation of plant growth and development. Its phenolic structure suggests potential antioxidant activity, although detailed in vitro pharmacological studies are limited. The compound is also used in the synthesis of (-)-centrolobine.
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| ln Vivo |
In vivo, 3-(4-Hydroxyphenyl)-1-propanol is a natural product found in various plant species. Its role in plant growth and development suggests it may function as a signaling molecule in plants. In animals, its effects would be dependent on the final compound synthesized from it. Detailed in vivo pharmacological studies are limited.
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| Enzyme Assay |
For in vitro synthesis protocols, 3-(4-Hydroxyphenyl)-1-propanol is used as a starting material or intermediate in organic synthesis. The compound is dissolved in a suitable solvent and reacted with appropriate reagents under controlled conditions. The reaction progress is monitored by TLC or HPLC. The product is purified by column chromatography or recrystallization and characterized by NMR and mass spectrometry.
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| Cell Assay |
For in vitro cell-based assays, 3-(4-Hydroxyphenyl)-1-propanol can be tested for its biological activity, particularly its potential antioxidant effects. Cells are treated with the compound at various concentrations (typically 1-100 µM) for 24-48 hours. Cellular oxidative stress markers, such as reactive oxygen species (ROS) levels, are measured using fluorescent probes. Cell viability is assessed using MTT assays.
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| Animal Protocol |
For in vivo animal experiments, 3-(4-Hydroxyphenyl)-1-propanol is not typically administered as a standalone compound. The compounds synthesized from it may be tested in animal models. The pharmacokinetics and pharmacodynamics of these compounds would be evaluated based on their specific targets. The compound itself is primarily used as a research intermediate.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 3-(4-Hydroxyphenyl)-1-propanol are limited, as it is primarily used as a chemical intermediate. As a small molecule with a molecular weight of 152.19 g/mol and formula C₉H₁₂O₂, it is expected to be rapidly absorbed and metabolized if administered. Its phenolic structure suggests it may undergo conjugation and oxidation in the liver.
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| Toxicity/Toxicokinetics |
Toxicological data for 3-(4-Hydroxyphenyl)-1-propanol are limited. As a phenolic compound, it may cause irritation at high concentrations. The compound is classified as a research-grade reagent and is not for human therapeutic use. Standard laboratory safety practices should be followed when handling.
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| Additional Infomation |
3-(4-hydroxyphenyl)-1-propanol is a type of phenolic compound. It has been reported to exist in Eucalyptus grandis, Taiwan cedar, and other organisms for which relevant data exists.
3-(4-Hydroxyphenyl)-1-propanol is a research-use only compound and has not been approved for clinical applications. Its molecular weight is 152.19, and its formula is C₉H₁₂O₂. The compound is available from various research chemical suppliers for organic synthesis and natural product research. It is used as a reagent in the synthesis of leukotriene biosynthesis inhibitors. |
| Molecular Formula |
C9H12O2
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|---|---|
| Molecular Weight |
152.1904
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| Exact Mass |
152.083
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| CAS # |
10210-17-0
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| PubChem CID |
82452
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| Appearance |
Off-white to light yellow solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
311.6±17.0 °C at 760 mmHg
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| Melting Point |
51-54ºC(lit.)
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| Flash Point |
154.4±15.5 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
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| Index of Refraction |
1.565
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| LogP |
1.14
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
11
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| Complexity |
95.7
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O([H])C([H])([H])C([H])([H])C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])O[H]
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| InChi Key |
NJCVPQRHRKYSAZ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C9H12O2/c10-7-1-2-8-3-5-9(11)6-4-8/h3-6,10-11H,1-2,7H2
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| Chemical Name |
4-(3-hydroxypropyl)phenol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~25 mg/mL (~164.27 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1 mg/mL (6.57 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 1 mg/mL (6.57 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 1 mg/mL (6.57 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.5707 mL | 32.8537 mL | 65.7073 mL | |
| 5 mM | 1.3141 mL | 6.5707 mL | 13.1415 mL | |
| 10 mM | 0.6571 mL | 3.2854 mL | 6.5707 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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