| Size | Price | Stock | Qty |
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| 5g |
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| 10g |
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| Other Sizes |
| Targets |
3,4-Dimethoxyphenol targets tyrosinase, inhibiting its activity. It also exhibits antioxidant effects and broad-spectrum antimicrobial activity. The compound can be used for the study of infection.
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|---|---|
| ln Vitro |
3,4-Dimethoxyphenol has tyrosinase-inhibiting activity and potent antioxidant effects. It exhibits broad-spectrum antimicrobial activity. These activities support its use in cosmetic and research applications.
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| ln Vivo |
In vivo activity of 3,4-Dimethoxyphenol is not extensively reported. As a plant-derived compound, it may have applications in topical formulations for skin whitening and as an antimicrobial agent.
|
| Enzyme Assay |
Tyrosinase inhibition assays are performed using mushroom tyrosinase and L-DOPA as substrate. The compound's ability to inhibit tyrosinase activity is measured spectrophotometrically. Antioxidant activity is assessed using standard assays such as DPPH radical scavenging.
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| Cell Assay |
Cell-based assays are conducted to evaluate the compound's antimicrobial activity and tyrosinase inhibition. The compound's effects on melanin production in melanocytes can be assessed.
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| Animal Protocol |
In vivo studies are not extensively reported. The compound is used as a whitening agent in cosmetics, suggesting topical application. Antimicrobial activity may support further in vivo studies.
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| ADME/Pharmacokinetics |
3,4-Dimethoxyphenol has a molecular weight of 154.16. It is a solid at room temperature. Storage: standard conditions for research compounds. The compound is soluble in organic solvents.
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| Toxicity/Toxicokinetics |
3,4-Dimethoxyphenol is not classified as a hazardous compound under normal handling conditions. Standard laboratory safety precautions should be followed when handling the compound.
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| References |
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| Additional Infomation |
Reports have indicated that camellia (Camellia crassicolumna) and croton (Croton lechleri) contain 3,4-dimethoxyphenol, and relevant data are available for reference.
3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound with tyrosinase-inhibiting, antioxidant, and broad-spectrum antimicrobial activities. It is used as a whitening agent in cosmetics and for research on infection. |
| Molecular Formula |
C₈H₁₀O₃
|
|---|---|
| Molecular Weight |
154.16
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| Exact Mass |
154.062
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| CAS # |
2033-89-8
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| PubChem CID |
16251
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| Appearance |
Off-white to yellow solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
271.2±20.0 °C at 760 mmHg
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| Melting Point |
79-82 °C(lit.)
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| Flash Point |
117.8±21.8 °C
|
| Vapour Pressure |
0.0±0.6 mmHg at 25°C
|
| Index of Refraction |
1.523
|
| LogP |
1.25
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| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
2
|
| Heavy Atom Count |
11
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| Complexity |
116
|
| Defined Atom Stereocenter Count |
0
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| InChi Key |
SMFFZOQLHYIRDA-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C8H10O3/c1-10-7-4-3-6(9)5-8(7)11-2/h3-5,9H,1-2H3
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| Chemical Name |
3,4-dimethoxyphenol
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| Synonyms |
3,4Dimethoxyphenol; 3,4 Dimethoxyphenol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~648.68 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.22 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.22 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (16.22 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.4868 mL | 32.4338 mL | 64.8677 mL | |
| 5 mM | 1.2974 mL | 6.4868 mL | 12.9735 mL | |
| 10 mM | 0.6487 mL | 3.2434 mL | 6.4868 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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