Size | Price | Stock | Qty |
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5mg |
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10mg |
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Other Sizes |
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ln Vitro |
In differentiated NG108-15 cells, (2R/S)-6-PNG (6-Prenylnaringenin) does not significantly affect voltage-gated Na+ channels or high-voltage-activated Ca2+ channels [1]. However, it can effectively block Cav3.2. The inhibitory potency of (2R/S)-6-PNG on Cav3.2 and HVA currents has an IC50 value of 5.20; consequently, the ratio of Cav3.2 and Nav currents is 3.54 (Cav3.2/Nav)[1].
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ln Vivo |
(2R/S)-6-PNG (6-prenylnaringenin; 10-30 mg/kg; i.p.; single dose; 15 min before Na2S) greatly lowers Na2S-induced intracolonic Nociceptive behavior and/or related hyperalgesia (i.col.) Administration of Na2S (an H2S donor) [1]. (2R/S)-6-PNG (30 mg/kg; i.p.) reduced the rise in the number of phosphorylated ERK-positive cells following i.col. Primary afferent neurons project to Na2S in layers I-II, V-VI and X, and Na2S generates an increase in the number of phosphorylated ERK-positive cells [1]. (2R/S)-6-PNG (0.01-1 and 0.1-10 nmol/paw; intraplantar injection) reversed mechanical damage caused by partial sciatic nerve ligation (PSNL) and intraperitoneal treatment of oxaliplatin (OHP)a, respectively Allodynia is dose-dependent [1]. (2R/S)-6-PNG (20-30 mg/kg; i.p.) effectively corrected PSNL-induced allodynia. (2R/S)-6-PNG (10-20 mg/kg; i.p.) effectively reverses OHP-induced allodynia (5 mg/kg; i.p.; single dose) [1].
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References |
[1]. Fumiko Sekiguchi, et al. Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice. Neuropharmacology
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Molecular Formula |
C20H20O5
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Molecular Weight |
340.3698
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CAS # |
68682-01-9
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Related CAS # |
(2S)-6-Prenylnaringenin;68236-13-5
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SMILES |
O1C2C([H])=C(C(C([H])([H])/C(/[H])=C(\C([H])([H])[H])/C([H])([H])[H])=C(C=2C(C([H])([H])C1([H])C1C([H])=C([H])C(=C([H])C=1[H])O[H])=O)O[H])O[H]
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~125 mg/mL (~367.25 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (6.11 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (6.11 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (6.11 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.9380 mL | 14.6899 mL | 29.3798 mL | |
5 mM | 0.5876 mL | 2.9380 mL | 5.8760 mL | |
10 mM | 0.2938 mL | 1.4690 mL | 2.9380 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.