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| Other Sizes |
| Targets |
2',4'-Dihydroxyacetophenone targets multiple pathways. It exhibits antimicrobial and antifungal activity. It has antioxidant activity due to the presence of hydroxyl groups. It is a selective P450 inhibitor. Its dual hydroxyl groups contribute to its antioxidant activity and enable further functionalization.
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| ln Vitro |
In vitro, 2',4'-Dihydroxyacetophenone demonstrates antioxidant and antimicrobial activities. It shows antifungal activity against 11 fungal strains. It has antioxidant activity, suggesting potential free radical scavenging properties. It is also used in the synthesis of flavonoids and UV-absorbers.
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| ln Vivo |
In vivo, 2',4'-Dihydroxyacetophenone is a plant metabolite. It is not used as a therapeutic agent. Its presence in plants may contribute to their defense mechanisms against pathogens. Its potential as a multifunctional preservative-supporting component and antioxidant ingredient in cosmetics has been explored.
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| Enzyme Assay |
The in vitro antioxidant assay for 2',4'-Dihydroxyacetophenone involves measuring its ability to scavenge free radicals, such as DPPH or ABTS. The compound is incubated with the radical, and the decrease in absorbance is measured. For antimicrobial activity, the minimum inhibitory concentration (MIC) is determined by the broth microdilution method.
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| Cell Assay |
In vitro cell culture studies for 2',4'-Dihydroxyacetophenone are not extensive. Its antioxidant effects can be studied by measuring its ability to reduce ROS levels in cells. Its antimicrobial effects can be studied by treating bacterial or fungal cultures with the compound and measuring the inhibition of growth. Its potential cytotoxicity can be assessed in various cell lines.
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| Animal Protocol |
In vivo animal experiments for 2',4'-Dihydroxyacetophenone are not common. Its antifungal activity could be studied in animal models of fungal infection. Its use as a cosmetic ingredient may be assessed in skin irritation tests. Its role as a plant metabolite can be studied in plant models.
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| ADME/Pharmacokinetics |
Metabolism / Metabolites
It is known that resorcinol has human metabolites including 2,4-dihydroxyacetophenone 5-sulfate. 2',4'-Dihydroxyacetophenone has a molecular formula of C8H8O3 and a molecular weight of 152.15 g/mol. It is a solid compound that is slightly soluble in water and soluble in organic solvents. It is typically stored as a powder at room temperature for long-term stability. Its stability is maintained under recommended storage conditions. It is a reddish-brown powder. |
| Toxicity/Toxicokinetics |
Toxicological data for 2',4'-Dihydroxyacetophenone are limited, as it is a research compound. It is a potential skin and eye irritant. As a research compound, it is not intended for human therapeutic use, and comprehensive toxicity studies are not available. Standard safety precautions should be followed.
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| References | |
| Additional Infomation |
2',4'-Dihydroxyacetophenone is an acetophenone with hydroxyl substituents at the 2' and 4' positions. It is a plant metabolite belonging to the resorcinol class of compounds. It has been reported to exist in Daldinia eschscholtzii, Vincetoxicum paniculatum, and other organisms with relevant data. See also: Root (part) of Paeonia x suffruticosa.
2',4'-Dihydroxyacetophenone is a research compound with no clinical approval. It is used as a building block in the synthesis of flavonoids, UV-absorbers, and other biologically active compounds. It also serves as a reference standard in analytical chemistry. Its antioxidant and antimicrobial properties make it a compound of interest for research into oxidative stress and infectious diseases. |
| Molecular Formula |
C8H8O3
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|---|---|
| Molecular Weight |
152.1473
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| Exact Mass |
152.047
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| CAS # |
89-84-9
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| PubChem CID |
6990
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| Appearance |
White to light brown solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
319.3±12.0 °C at 760 mmHg
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| Melting Point |
143-144.5 °C(lit.)
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| Flash Point |
161.1±16.1 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
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| Index of Refraction |
1.595
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| LogP |
1.74
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
11
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| Complexity |
155
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
SULYEHHGGXARJS-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C8H8O3/c1-5(9)7-3-2-6(10)4-8(7)11/h2-4,10-11H,1H3
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| Chemical Name |
1-(2,4-dihydroxyphenyl)ethanone
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~657.25 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.43 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.43 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (16.43 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.5725 mL | 32.8623 mL | 65.7246 mL | |
| 5 mM | 1.3145 mL | 6.5725 mL | 13.1449 mL | |
| 10 mM | 0.6572 mL | 3.2862 mL | 6.5725 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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