| Size | Price | Stock | Qty |
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| 100mg |
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| 500mg |
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| Other Sizes |
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| ln Vitro |
In response to food consumption, 2,4-Diamino-6-hydroxypyrimidine (DAHP) shows decreased generation of NO in chicken peritoneal macrophages (PEC) and the avian MC29 virus-transformed macrophage cell line HD11 [1]. In HUVEC cells, treatment with 2,4-Diamino-6-hydroxypyrimidine (DAHP; 5 mM; 24 h) dramatically lowered the amounts of BH4 and VCAM-1. 2,4-Diamino-6-hydroxypyrimidine (DAHP) was initially discovered as a biopterin framework for collagenous animal Crithidia fascicuLate growth stent[2]. It did this, at least in part, by suppressing NF-κB levels in HUVEC nuclei.
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| ln Vivo |
Serotonin levels in the duodenum and blood vessels of mice treated with 2,4-diamino-6-hydroxypyrimidine (DAHP) at a dose of 3 g/kg/day for 4 days were roughly 46% and 40% of control levels, respectively. All organs tested, with the exception of the brain, showed a sharp decline in BH4 levels (T1/2 less than 12 hours) in response to 2,4-Diamino-6-hydroxypyrimidine. The levels of BH4 restored to normal less than 24 hours after the injection of 2,4-diamino-6-hydroxypyrimidine was stopped [3].
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| References |
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| Additional Infomation |
2,4-Diamino-6-hydroxypyrimidine is a hydroxypyrimidine.
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| Molecular Formula |
C4H6N4O
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|---|---|
| Molecular Weight |
126.1166
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| Exact Mass |
126.054
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| CAS # |
56-06-4
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| Related CAS # |
58470-85-2 (sulfate)
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| PubChem CID |
135408763
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| Appearance |
Off-white to light yellow solid powder
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| Density |
1.6±0.1 g/cm3
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| Boiling Point |
524.0±53.0 °C at 760 mmHg
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| Melting Point |
285-286 °C (dec.)(lit.)
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| Flash Point |
270.7±30.9 °C
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| Vapour Pressure |
0.0±1.4 mmHg at 25°C
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| Index of Refraction |
1.770
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| LogP |
-1.29
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
9
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| Complexity |
205
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
SWELIMKTDYHAOY-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C4H6N4O/c5-2-1-3(9)8-4(6)7-2/h1H,(H5,5,6,7,8,9)
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| Chemical Name |
2,4-diamino-1H-pyrimidin-6-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~16.67 mg/mL (~132.18 mM)
H2O : ~10 mg/mL (~79.29 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.67 mg/mL (13.24 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.67 mg/mL (13.24 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 1.67 mg/mL (13.24 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 6.5 mg/mL (51.54 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.9290 mL | 39.6448 mL | 79.2896 mL | |
| 5 mM | 1.5858 mL | 7.9290 mL | 15.8579 mL | |
| 10 mM | 0.7929 mL | 3.9645 mL | 7.9290 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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