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| Other Sizes |
| Targets |
2-Phenylglycine is a building block and intermediate used in the synthesis of various bioactive compounds. It has been used in the synthesis of HCV NS3 protease inhibitors, which target the viral protease essential for HCV replication. It is also used to synthesize compounds with fungicidal activity and benzoquinone-amino acid conjugates with antibacterial activity. As a metabolite, it may also have biological activities, but its primary role in research is as a synthetic intermediate.
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| ln Vitro |
2-Phenylglycine exhibits in vitro activity primarily as a chemical intermediate. It is used in the synthesis of HCV NS3 protease inhibitors, fungicidal compounds, and antibacterial benzoquinone-amino acid conjugates. Its activity is assessed in chemical synthesis reactions, where it serves as a precursor for more complex molecules. The biological activity of the final compounds is evaluated in appropriate assays. These in vitro activities confirm its value as a building block in medicinal chemistry.
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| ln Vivo |
2-Phenylglycine is not typically used as a therapeutic agent in vivo. However, its derivatives, such as HCV NS3 protease inhibitors, may have therapeutic applications. As a metabolite found in breast milk, it may also have physiological roles. Its in vivo effects are not relevant to its primary use as a chemical building block.
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| Enzyme Assay |
In vitro assays for 2-Phenylglycine are chemical rather than biological. The compound's utility as a building block is assessed by its reactivity in organic synthesis reactions. The formation of HCV NS3 protease inhibitors, fungicidal compounds, or antibacterial conjugates from 2-phenylglycine is monitored by analytical techniques such as NMR, HPLC, or mass spectrometry. These assays confirm the compound's suitability for the synthesis of bioactive molecules.
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| Cell Assay |
2-Phenylglycine is not typically used in cellular assays, as it is a chemical reagent rather than a biological agent. However, its derivatives, such as HCV NS3 protease inhibitors or antibacterial compounds, may be tested in cellular assays. These assays would assess the biological activity of the final compounds, not 2-phenylglycine itself.
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| Animal Protocol |
2-Phenylglycine is not used in animal experiments as a therapeutic agent. However, its derivatives, such as HCV NS3 protease inhibitors, may be tested in animal models of HCV infection. These studies would evaluate the efficacy of the final compounds, not 2-phenylglycine itself.
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| ADME/Pharmacokinetics |
2-Phenylglycine is a small, polar molecule with a molecular weight of 151.16. It is soluble in water and organic solvents. Its pharmacokinetic profile is not relevant to its primary use as a chemical building block. The compound is typically stored at room temperature.
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| Toxicity/Toxicokinetics |
2-Phenylglycine is considered to have low toxicity based on its use as a research compound. However, comprehensive toxicological evaluations have not been extensively published. The compound is intended for research use only and is not approved for human therapeutic use. Standard laboratory safety precautions should be followed when handling this compound.
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| References | |
| Additional Infomation |
α-Phenylglycine is an amino acid in which a benzene ring is attached to the α-carbon atom of glycine. It is a metabolic product in humans. 2-N-2-phenylacetic acid ester has been reported in Streptomyces pristinaespiralis and Trypanosoma brucei, and relevant data are available.
2-Phenylglycine is a building block and intermediate used in the synthesis of various bioactive compounds. It is also known as DL-α-phenylglycine or α-phenylglycine. The compound is a metabolite found in breast milk during lactation. It is used in the synthesis of HCV NS3 protease inhibitors, fungicidal compounds, and antibacterial conjugates. It is available in high purity (>95%) for research applications. Its versatility as a building block makes it a valuable tool in medicinal chemistry. |
| Molecular Formula |
C₈H₉NO₂
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|---|---|
| Molecular Weight |
151.16
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| Exact Mass |
151.063
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| CAS # |
2835-06-5
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| Related CAS # |
2-Phenylglycine-d5;358731-96-1
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| PubChem CID |
3866
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
288.7±28.0 °C at 760 mmHg
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| Melting Point |
121-127ºC
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| Flash Point |
128.4±24.0 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
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| Index of Refraction |
1.589
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| LogP |
0.94
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
11
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| Complexity |
141
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
ZGUNAGUHMKGQNY-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C8H9NO2/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7H,9H2,(H,10,11)
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| Chemical Name |
2-amino-2-phenylacetic acid
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| Synonyms |
2Phenylglycine; 2 Phenylglycine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~3.33 mg/mL (~22.03 mM)
DMSO :< 1 mg/mL |
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| Solubility (In Vivo) |
Solubility in Formulation 1: 2 mg/mL (13.23 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.6155 mL | 33.0775 mL | 66.1551 mL | |
| 5 mM | 1.3231 mL | 6.6155 mL | 13.2310 mL | |
| 10 mM | 0.6616 mL | 3.3078 mL | 6.6155 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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